| http://purl.uniprot.org/citations/25721419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25721419 | http://www.w3.org/2000/01/rdf-schema#comment | "An F-box protein, β-TrCP recognizes substrate proteins and destabilizes them through ubiquitin-dependent proteolysis. It regulates the stability of diverse proteins and functions as either a tumor suppressor or an oncogene. Although the regulation by β-TrCP has been widely studied, the regulation of β-TrCP itself is not well understood yet. In this study, we found that the level of β-TrCP1 is downregulated by various protein kinase inhibitors in triple-negative breast cancer (TNBC) cells. A PI3K/mTOR inhibitor PI-103 reduced the level of β-TrCP1 in a wide range of TNBC cells in a proteasome-dependent manner. Concomitantly, the levels of c-Myc and cyclin E were also downregulated by PI-103. PI-103 reduced the phosphorylation of β-TrCP1 prior to its degradation. In addition, knockdown of β-TrCP1 inhibited the proliferation of TNBC cells. We further identified that pharmacological inhibition of mTORC2 was sufficient to reduce the β-TrCP1 and c-Myc levels. These results suggest that mTORC2 regulates the stability of β-TrCP1 in TNBC cells and targeting β-TrCP1 is a potential approach to treat human TNBC."xsd:string |
| http://purl.uniprot.org/citations/25721419 | http://purl.org/dc/terms/identifier | "doi:10.1038/emm.2014.127"xsd:string |
| http://purl.uniprot.org/citations/25721419 | http://purl.uniprot.org/core/author | "Oh S."xsd:string |
| http://purl.uniprot.org/citations/25721419 | http://purl.uniprot.org/core/author | "Kang H.J."xsd:string |
| http://purl.uniprot.org/citations/25721419 | http://purl.uniprot.org/core/author | "Seong Y.S."xsd:string |
| http://purl.uniprot.org/citations/25721419 | http://purl.uniprot.org/core/author | "Bae E.J."xsd:string |
| http://purl.uniprot.org/citations/25721419 | http://purl.uniprot.org/core/author | "Bae I."xsd:string |
| http://purl.uniprot.org/citations/25721419 | http://purl.uniprot.org/core/author | "Yi Y.W."xsd:string |
| http://purl.uniprot.org/citations/25721419 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25721419 | http://purl.uniprot.org/core/name | "Exp Mol Med"xsd:string |
| http://purl.uniprot.org/citations/25721419 | http://purl.uniprot.org/core/pages | "e143"xsd:string |
| http://purl.uniprot.org/citations/25721419 | http://purl.uniprot.org/core/title | "beta-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/25721419 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/25721419 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25721419 |
| http://purl.uniprot.org/citations/25721419 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25721419 |
| http://purl.uniprot.org/uniprot/#_P42345-mappedCitation-25721419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25721419 |
| http://purl.uniprot.org/uniprot/P42345 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25721419 |