| http://purl.uniprot.org/citations/25759381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25759381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25759381 | http://www.w3.org/2000/01/rdf-schema#comment | "We recently discovered signal-regulated nuclear actin network assembly. However, in contrast to cytoplasmic actin regulation, polymeric nuclear actin structures and functions remain only poorly understood. Here we describe a novel molecular tool to visualize real-time nuclear actin dynamics by targeting the Actin-Chromobody-TagGFP to the nucleus, thus establishing a nuclear Actin-Chromobody. Interestingly, we observe nuclear actin polymerization into dynamic filaments upon cell spreading and fibronectin stimulation, both of which appear to be triggered by integrin signaling. Furthermore, we show that nucleoskeletal proteins such as the LINC (linker of nucleoskeleton and cytoskeleton) complex and components of the nuclear lamina couple cell spreading or integrin activation by fibronectin to nuclear actin polymerization. Spreading-induced nuclear actin polymerization results in serum response factor (SRF)-mediated transcription through nuclear retention of myocardin-related transcription factor A (MRTF-A). Our results reveal a signaling pathway, which links integrin activation by extracellular matrix interaction to nuclear actin polymerization through the LINC complex, and therefore suggest a role for nuclear actin polymerization in the context of cellular adhesion and mechanosensing."xsd:string |
| http://purl.uniprot.org/citations/25759381 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.627166"xsd:string |
| http://purl.uniprot.org/citations/25759381 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.627166"xsd:string |
| http://purl.uniprot.org/citations/25759381 | http://purl.uniprot.org/core/author | "Grosse R."xsd:string |
| http://purl.uniprot.org/citations/25759381 | http://purl.uniprot.org/core/author | "Grosse R."xsd:string |
| http://purl.uniprot.org/citations/25759381 | http://purl.uniprot.org/core/author | "Baarlink C."xsd:string |
| http://purl.uniprot.org/citations/25759381 | http://purl.uniprot.org/core/author | "Baarlink C."xsd:string |
| http://purl.uniprot.org/citations/25759381 | http://purl.uniprot.org/core/author | "Chinchilla P."xsd:string |
| http://purl.uniprot.org/citations/25759381 | http://purl.uniprot.org/core/author | "Chinchilla P."xsd:string |
| http://purl.uniprot.org/citations/25759381 | http://purl.uniprot.org/core/author | "Melak M."xsd:string |
| http://purl.uniprot.org/citations/25759381 | http://purl.uniprot.org/core/author | "Melak M."xsd:string |
| http://purl.uniprot.org/citations/25759381 | http://purl.uniprot.org/core/author | "Plessner M."xsd:string |
| http://purl.uniprot.org/citations/25759381 | http://purl.uniprot.org/core/author | "Plessner M."xsd:string |
| http://purl.uniprot.org/citations/25759381 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25759381 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25759381 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/25759381 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/25759381 | http://purl.uniprot.org/core/pages | "11209-11216"xsd:string |
| http://purl.uniprot.org/citations/25759381 | http://purl.uniprot.org/core/pages | "11209-11216"xsd:string |
| http://purl.uniprot.org/citations/25759381 | http://purl.uniprot.org/core/title | "Nuclear F-actin formation and reorganization upon cell spreading."xsd:string |
| http://purl.uniprot.org/citations/25759381 | http://purl.uniprot.org/core/title | "Nuclear F-actin formation and reorganization upon cell spreading."xsd:string |
| http://purl.uniprot.org/citations/25759381 | http://purl.uniprot.org/core/volume | "290"xsd:string |
| http://purl.uniprot.org/citations/25759381 | http://purl.uniprot.org/core/volume | "290"xsd:string |