| http://purl.uniprot.org/citations/25820262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25820262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25820262 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations of CSB account for the majority of Cockayne syndrome (CS), a devastating hereditary disorder characterized by physical impairment, neurological degeneration and segmental premature aging. Here we report the generation of a human CSB-knockout cell line. We find that CSB facilitates HR and represses NHEJ. Loss of CSB or a CS-associated CSB mutation abrogating its ATPase activity impairs the recruitment of BRCA1, RPA and Rad51 proteins to damaged chromatin but promotes the formation of 53BP1-Rif1 damage foci in S and G2 cells. Depletion of 53BP1 rescues the formation of BRCA1 damage foci in CSB-knockout cells. In addition, knockout of CSB impairs the ATM- and Chk2-mediated DNA damage responses, promoting a premature entry into mitosis. Furthermore, we show that CSB accumulates at sites of DNA double-strand breaks (DSBs) in a transcription-dependent manner. The kinetics of DSB-induced chromatin association of CSB is distinct from that of its UV-induced chromatin association. These results reveal novel, important functions of CSB in regulating the DNA DSB repair pathway choice as well as G2/M checkpoint activation."xsd:string |
| http://purl.uniprot.org/citations/25820262 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.201490041"xsd:string |
| http://purl.uniprot.org/citations/25820262 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.201490041"xsd:string |
| http://purl.uniprot.org/citations/25820262 | http://purl.uniprot.org/core/author | "Batenburg N.L."xsd:string |
| http://purl.uniprot.org/citations/25820262 | http://purl.uniprot.org/core/author | "Batenburg N.L."xsd:string |
| http://purl.uniprot.org/citations/25820262 | http://purl.uniprot.org/core/author | "Zhu X.D."xsd:string |
| http://purl.uniprot.org/citations/25820262 | http://purl.uniprot.org/core/author | "Zhu X.D."xsd:string |
| http://purl.uniprot.org/citations/25820262 | http://purl.uniprot.org/core/author | "Hendrickson E.A."xsd:string |
| http://purl.uniprot.org/citations/25820262 | http://purl.uniprot.org/core/author | "Hendrickson E.A."xsd:string |
| http://purl.uniprot.org/citations/25820262 | http://purl.uniprot.org/core/author | "Thompson E.L."xsd:string |
| http://purl.uniprot.org/citations/25820262 | http://purl.uniprot.org/core/author | "Thompson E.L."xsd:string |
| http://purl.uniprot.org/citations/25820262 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25820262 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25820262 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/25820262 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/25820262 | http://purl.uniprot.org/core/pages | "1399-1416"xsd:string |
| http://purl.uniprot.org/citations/25820262 | http://purl.uniprot.org/core/pages | "1399-1416"xsd:string |
| http://purl.uniprot.org/citations/25820262 | http://purl.uniprot.org/core/title | "Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation."xsd:string |
| http://purl.uniprot.org/citations/25820262 | http://purl.uniprot.org/core/title | "Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation."xsd:string |
| http://purl.uniprot.org/citations/25820262 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/25820262 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/25820262 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25820262 |
| http://purl.uniprot.org/citations/25820262 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25820262 |