| http://purl.uniprot.org/citations/25917219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25917219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25917219 | http://www.w3.org/2000/01/rdf-schema#comment | "Wnts are a conserved family of secreted glycoproteins that regulate various developmental processes in metazoans. Three of the five Caenorhabditis elegans Wnts, CWN-1, CWN-2 and EGL-20, and the sole Wnt receptor of the Ror kinase family, CAM-1, are known to regulate the anterior polarization of the mechanosensory neuron ALM. Here we show that CAM-1 and the Frizzled receptor MOM-5 act in parallel pathways to control ALM polarity. We also show that CAM-1 has two functions in this process: an autonomous signaling function that promotes anterior polarization and a nonautonomous Wnt-antagonistic function that inhibits anterior polarization. These antagonistic activities can account for the weak ALM phenotypes displayed by cam-1 mutants. Our observations suggest that CAM-1 could function as a Wnt receptor in many developmental processes, but the analysis of cam-1 mutants may fail to reveal CAM-1's role as a receptor in these processes because of its Wnt-antagonistic activity. In this model, loss of CAM-1 results in increased levels of Wnts that act through other Wnt receptors, masking CAM-1's autonomous role as a Wnt receptor."xsd:string |
| http://purl.uniprot.org/citations/25917219 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2015.04.015"xsd:string |
| http://purl.uniprot.org/citations/25917219 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2015.04.015"xsd:string |
| http://purl.uniprot.org/citations/25917219 | http://purl.uniprot.org/core/author | "Kim C."xsd:string |
| http://purl.uniprot.org/citations/25917219 | http://purl.uniprot.org/core/author | "Kim C."xsd:string |
| http://purl.uniprot.org/citations/25917219 | http://purl.uniprot.org/core/author | "Garriga G."xsd:string |
| http://purl.uniprot.org/citations/25917219 | http://purl.uniprot.org/core/author | "Garriga G."xsd:string |
| http://purl.uniprot.org/citations/25917219 | http://purl.uniprot.org/core/author | "Chien S.C."xsd:string |
| http://purl.uniprot.org/citations/25917219 | http://purl.uniprot.org/core/author | "Chien S.C."xsd:string |
| http://purl.uniprot.org/citations/25917219 | http://purl.uniprot.org/core/author | "Craft T."xsd:string |
| http://purl.uniprot.org/citations/25917219 | http://purl.uniprot.org/core/author | "Craft T."xsd:string |
| http://purl.uniprot.org/citations/25917219 | http://purl.uniprot.org/core/author | "Forrester W."xsd:string |
| http://purl.uniprot.org/citations/25917219 | http://purl.uniprot.org/core/author | "Forrester W."xsd:string |
| http://purl.uniprot.org/citations/25917219 | http://purl.uniprot.org/core/author | "Gurling M."xsd:string |
| http://purl.uniprot.org/citations/25917219 | http://purl.uniprot.org/core/author | "Gurling M."xsd:string |
| http://purl.uniprot.org/citations/25917219 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25917219 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25917219 | http://purl.uniprot.org/core/name | "Dev. Biol."xsd:string |
| http://purl.uniprot.org/citations/25917219 | http://purl.uniprot.org/core/name | "Dev. Biol."xsd:string |
| http://purl.uniprot.org/citations/25917219 | http://purl.uniprot.org/core/pages | "55-65"xsd:string |
| http://purl.uniprot.org/citations/25917219 | http://purl.uniprot.org/core/pages | "55-65"xsd:string |
| http://purl.uniprot.org/citations/25917219 | http://purl.uniprot.org/core/title | "Autonomous and nonautonomous regulation of Wnt-mediated neuronal polarity by the C. elegans Ror kinase CAM-1."xsd:string |
| http://purl.uniprot.org/citations/25917219 | http://purl.uniprot.org/core/title | "Autonomous and nonautonomous regulation of Wnt-mediated neuronal polarity by the C. elegans Ror kinase CAM-1."xsd:string |