http://purl.uniprot.org/citations/26169693 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/26169693 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at post-transcriptional level. miRNA dysregulation plays a causal role in cancer progression. In this study, miR-208-3p was highly expressed and directly repressed ARID2 expression. As a result, ARID2 expression in hepatocellular carcinoma (HCC) was decreased. In vitro, miR-208-3p down-regulation and ARID2 over-expression elicited similar inhibitory effects on HCC cell proliferation and invasion. In vivo test results revealed that miR-208-3p down-regulation inhibited HCC tumorigenesis in Hep3B cells. Moreover, ARID2 was possibly a downstream element of transforming growth factor beta1 (TGFβ1)/miR-208-3p/ARID2 regulatory pathway. These findings suggested that miR-208-3p up-regulation is associated with HCC cell progression and may provide a new target for liver cancer treatment."xsd:string |
http://purl.uniprot.org/citations/26169693 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2015.07.008"xsd:string |
http://purl.uniprot.org/citations/26169693 | http://purl.uniprot.org/core/author | "Lu L."xsd:string |
http://purl.uniprot.org/citations/26169693 | http://purl.uniprot.org/core/author | "Wu D."xsd:string |
http://purl.uniprot.org/citations/26169693 | http://purl.uniprot.org/core/author | "Tan J."xsd:string |
http://purl.uniprot.org/citations/26169693 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
http://purl.uniprot.org/citations/26169693 | http://purl.uniprot.org/core/author | "You Y."xsd:string |
http://purl.uniprot.org/citations/26169693 | http://purl.uniprot.org/core/author | "Yu P."xsd:string |
http://purl.uniprot.org/citations/26169693 | http://purl.uniprot.org/core/author | "Bie P."xsd:string |
http://purl.uniprot.org/citations/26169693 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
http://purl.uniprot.org/citations/26169693 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
http://purl.uniprot.org/citations/26169693 | http://purl.uniprot.org/core/pages | "232-241"xsd:string |
http://purl.uniprot.org/citations/26169693 | http://purl.uniprot.org/core/title | "miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression."xsd:string |
http://purl.uniprot.org/citations/26169693 | http://purl.uniprot.org/core/volume | "336"xsd:string |
http://purl.uniprot.org/citations/26169693 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26169693 |
http://purl.uniprot.org/citations/26169693 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26169693 |
http://purl.uniprot.org/uniprot/Q68CP9#attribution-224EC8D764992BE75C267A77244F33E7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26169693 |