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http://purl.uniprot.org/citations/26169693http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26169693http://www.w3.org/2000/01/rdf-schema#comment"MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at post-transcriptional level. miRNA dysregulation plays a causal role in cancer progression. In this study, miR-208-3p was highly expressed and directly repressed ARID2 expression. As a result, ARID2 expression in hepatocellular carcinoma (HCC) was decreased. In vitro, miR-208-3p down-regulation and ARID2 over-expression elicited similar inhibitory effects on HCC cell proliferation and invasion. In vivo test results revealed that miR-208-3p down-regulation inhibited HCC tumorigenesis in Hep3B cells. Moreover, ARID2 was possibly a downstream element of transforming growth factor beta1 (TGFβ1)/miR-208-3p/ARID2 regulatory pathway. These findings suggested that miR-208-3p up-regulation is associated with HCC cell progression and may provide a new target for liver cancer treatment."xsd:string
http://purl.uniprot.org/citations/26169693http://purl.org/dc/terms/identifier"doi:10.1016/j.yexcr.2015.07.008"xsd:string
http://purl.uniprot.org/citations/26169693http://purl.uniprot.org/core/author"Lu L."xsd:string
http://purl.uniprot.org/citations/26169693http://purl.uniprot.org/core/author"Wu D."xsd:string
http://purl.uniprot.org/citations/26169693http://purl.uniprot.org/core/author"Tan J."xsd:string
http://purl.uniprot.org/citations/26169693http://purl.uniprot.org/core/author"Sun J."xsd:string
http://purl.uniprot.org/citations/26169693http://purl.uniprot.org/core/author"You Y."xsd:string
http://purl.uniprot.org/citations/26169693http://purl.uniprot.org/core/author"Yu P."xsd:string
http://purl.uniprot.org/citations/26169693http://purl.uniprot.org/core/author"Bie P."xsd:string
http://purl.uniprot.org/citations/26169693http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/26169693http://purl.uniprot.org/core/name"Exp Cell Res"xsd:string
http://purl.uniprot.org/citations/26169693http://purl.uniprot.org/core/pages"232-241"xsd:string
http://purl.uniprot.org/citations/26169693http://purl.uniprot.org/core/title"miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression."xsd:string
http://purl.uniprot.org/citations/26169693http://purl.uniprot.org/core/volume"336"xsd:string
http://purl.uniprot.org/citations/26169693http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26169693
http://purl.uniprot.org/citations/26169693http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/26169693
http://purl.uniprot.org/uniprot/Q68CP9#attribution-224EC8D764992BE75C267A77244F33E7http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/26169693