RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/26223809http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26223809http://www.w3.org/2000/01/rdf-schema#comment"

Background

Pregnancy-associated plasma protein-A (PAPP-A) is discussed as a biomarker representing unstable plaques in coronary artery disease (CAD).

Methods

In this study 927 patients with CAD (534 with stable angina and 393 with acute coronary syndrome [ACS]) and 217 patients without CAD and measured PAPP-A levels were included. Follow-up for a median of 5 years was documented.

Results

Rising quartiles of PAPP-A concentration had a higher cardiovascular mortality in the overall cohort of patients with CAD (p = 0.002) and the cohort with ACS (p = 0.01). Patients with suspected ACS below the LOD for troponin I but elevated PAPP-A levels had an increased cardiovascular mortality. A cut-off of 11.4 IU/l identified patients with a higher mortality during follow-up.

Conclusion

Rising PAPP-A levels are prognostic in patients with CAD. PAPP-A levels were especially predictive in ACS patients with troponin below 10% CV of the 99 th percentile for cardiovascular mortality."xsd:string
http://purl.uniprot.org/citations/26223809http://purl.org/dc/terms/identifier"doi:10.2217/bmm.15.41"xsd:string
http://purl.uniprot.org/citations/26223809http://purl.uniprot.org/core/author"Lackner K.J."xsd:string
http://purl.uniprot.org/citations/26223809http://purl.uniprot.org/core/author"Blankenberg S."xsd:string
http://purl.uniprot.org/citations/26223809http://purl.uniprot.org/core/author"Zeller T."xsd:string
http://purl.uniprot.org/citations/26223809http://purl.uniprot.org/core/author"Zengin E."xsd:string
http://purl.uniprot.org/citations/26223809http://purl.uniprot.org/core/author"Bickel C."xsd:string
http://purl.uniprot.org/citations/26223809http://purl.uniprot.org/core/author"Schnabel R.B."xsd:string
http://purl.uniprot.org/citations/26223809http://purl.uniprot.org/core/author"Rupprecht H.J."xsd:string
http://purl.uniprot.org/citations/26223809http://purl.uniprot.org/core/author"Westermann D."xsd:string
http://purl.uniprot.org/citations/26223809http://purl.uniprot.org/core/author"Sinning C."xsd:string
http://purl.uniprot.org/citations/26223809http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/26223809http://purl.uniprot.org/core/name"Biomark Med"xsd:string
http://purl.uniprot.org/citations/26223809http://purl.uniprot.org/core/pages"731-741"xsd:string
http://purl.uniprot.org/citations/26223809http://purl.uniprot.org/core/title"The utility of pregnancy-associated plasma protein A for determination of prognosis in a cohort of patients with coronary artery disease."xsd:string
http://purl.uniprot.org/citations/26223809http://purl.uniprot.org/core/volume"9"xsd:string
http://purl.uniprot.org/citations/26223809http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26223809
http://purl.uniprot.org/citations/26223809http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/26223809
http://purl.uniprot.org/uniprot/#_B4DTA7-mappedCitation-26223809http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26223809
http://purl.uniprot.org/uniprot/#_B4DTA8-mappedCitation-26223809http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26223809
http://purl.uniprot.org/uniprot/#_Q13219-mappedCitation-26223809http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26223809
http://purl.uniprot.org/uniprot/#_Q5QFB7-mappedCitation-26223809http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26223809
http://purl.uniprot.org/uniprot/#_Q86YM8-mappedCitation-26223809http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26223809
http://purl.uniprot.org/uniprot/#_Q7Z613-mappedCitation-26223809http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26223809