| http://purl.uniprot.org/citations/26395742 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26395742 | http://www.w3.org/2000/01/rdf-schema#comment | "Circulating microRNAs (miRNAs) have emerged as novel biomarkers of diabetes. The current study focuses on the role of circulating miRNAs in patients with type 1 diabetes and their association with diabetic retinopathy. A total of 29 miRNAs were quantified in serum samples (n = 300) using a nested case-control study design in two prospective cohorts of the DIabetic REtinopathy Candesartan Trial (DIRECT): PROTECT-1 and PREVENT-1. The PREVENT-1 trial included patients without retinopathy at baseline; the PROTECT-1 trial included patients with nonproliferative retinopathy at baseline. Two miRNAs previously implicated in angiogenesis, miR-27b and miR-320a, were associated with incidence and with progression of retinopathy: the odds ratio per SD higher miR-27b was 0.57 (95% CI 0.40, 0.82; P = 0.002) in PREVENT-1, 0.78 (0.57, 1.07; P = 0.124) in PROTECT-1, and 0.67 (0.50, 0.92; P = 0.012) combined. The respective odds ratios for higher miR-320a were 1.57 (1.07, 2.31; P = 0.020), 1.43 (1.05, 1.94; P = 0.021), and 1.48 (1.17, 1.88; P = 0.001). Proteomics analyses in endothelial cells returned the antiangiogenic protein thrombospondin-1 as a common target of both miRNAs. Our study identifies two angiogenic miRNAs, miR-320a and miR-27b, as potential biomarkers for diabetic retinopathy."xsd:string |
| http://purl.uniprot.org/citations/26395742 | http://purl.org/dc/terms/identifier | "doi:10.2337/db15-0389"xsd:string |
| http://purl.uniprot.org/citations/26395742 | http://purl.uniprot.org/core/author | "Burr S."xsd:string |
| http://purl.uniprot.org/citations/26395742 | http://purl.uniprot.org/core/author | "Klein R."xsd:string |
| http://purl.uniprot.org/citations/26395742 | http://purl.uniprot.org/core/author | "Yin X."xsd:string |
| http://purl.uniprot.org/citations/26395742 | http://purl.uniprot.org/core/author | "Chaturvedi N."xsd:string |
| http://purl.uniprot.org/citations/26395742 | http://purl.uniprot.org/core/author | "Mayr M."xsd:string |
| http://purl.uniprot.org/citations/26395742 | http://purl.uniprot.org/core/author | "Zampetaki A."xsd:string |
| http://purl.uniprot.org/citations/26395742 | http://purl.uniprot.org/core/author | "Willeit P."xsd:string |
| http://purl.uniprot.org/citations/26395742 | http://purl.uniprot.org/core/author | "Kiechl S."xsd:string |
| http://purl.uniprot.org/citations/26395742 | http://purl.uniprot.org/core/author | "Langley S.R."xsd:string |
| http://purl.uniprot.org/citations/26395742 | http://purl.uniprot.org/core/author | "Rossing P."xsd:string |
| http://purl.uniprot.org/citations/26395742 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26395742 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/26395742 | http://purl.uniprot.org/core/pages | "216-227"xsd:string |
| http://purl.uniprot.org/citations/26395742 | http://purl.uniprot.org/core/title | "Angiogenic microRNAs Linked to Incidence and Progression of Diabetic Retinopathy in Type 1 Diabetes."xsd:string |
| http://purl.uniprot.org/citations/26395742 | http://purl.uniprot.org/core/volume | "65"xsd:string |
| http://purl.uniprot.org/citations/26395742 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26395742 |
| http://purl.uniprot.org/citations/26395742 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26395742 |
| http://purl.uniprot.org/uniprot/P07996#attribution-FDC88A809DFC2D75B7F3898232397DB0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26395742 |