| http://purl.uniprot.org/citations/26439302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26439302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26439302 | http://www.w3.org/2000/01/rdf-schema#comment | "AF10, a DOT1L cofactor, is required for H3K79 methylation and cooperates with DOT1L in leukemogenesis. However, the molecular mechanism by which AF10 regulates DOT1L-mediated H3K79 methylation is not clear. Here we report that AF10 contains a "reader" domain that couples unmodified H3K27 recognition to H3K79 methylation. An AF10 region consisting of a PHD finger-Zn knuckle-PHD finger (PZP) folds into a single module that recognizes amino acids 22-27 of H3, and this interaction is abrogated by H3K27 modification. Structural studies reveal that H3 binding triggers rearrangement of the PZP module to form an H3(22-27)-accommodating channel and that the unmodified H3K27 side chain is encased in a compact hydrogen-bond acceptor-lined cage. In cells, PZP recognition of H3 is required for H3K79 dimethylation, expression of DOT1L-target genes, and proliferation of DOT1L-addicted leukemic cells. Together, our results uncover a pivotal role for H3K27-via readout by the AF10 PZP domain-in regulating the cancer-associated enzyme DOT1L."xsd:string |
| http://purl.uniprot.org/citations/26439302 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2015.08.019"xsd:string |
| http://purl.uniprot.org/citations/26439302 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2015.08.019"xsd:string |
| http://purl.uniprot.org/citations/26439302 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/26439302 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/26439302 | http://purl.uniprot.org/core/author | "Patel D.J."xsd:string |
| http://purl.uniprot.org/citations/26439302 | http://purl.uniprot.org/core/author | "Patel D.J."xsd:string |
| http://purl.uniprot.org/citations/26439302 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/26439302 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/26439302 | http://purl.uniprot.org/core/author | "Garcia B.A."xsd:string |
| http://purl.uniprot.org/citations/26439302 | http://purl.uniprot.org/core/author | "Garcia B.A."xsd:string |
| http://purl.uniprot.org/citations/26439302 | http://purl.uniprot.org/core/author | "Strahl B.D."xsd:string |
| http://purl.uniprot.org/citations/26439302 | http://purl.uniprot.org/core/author | "Strahl B.D."xsd:string |
| http://purl.uniprot.org/citations/26439302 | http://purl.uniprot.org/core/author | "Gozani O."xsd:string |
| http://purl.uniprot.org/citations/26439302 | http://purl.uniprot.org/core/author | "Gozani O."xsd:string |
| http://purl.uniprot.org/citations/26439302 | http://purl.uniprot.org/core/author | "Wilkinson A.W."xsd:string |
| http://purl.uniprot.org/citations/26439302 | http://purl.uniprot.org/core/author | "Wilkinson A.W."xsd:string |
| http://purl.uniprot.org/citations/26439302 | http://purl.uniprot.org/core/author | "Armstrong S.A."xsd:string |
| http://purl.uniprot.org/citations/26439302 | http://purl.uniprot.org/core/author | "Armstrong S.A."xsd:string |
| http://purl.uniprot.org/citations/26439302 | http://purl.uniprot.org/core/author | "Deshpande A.J."xsd:string |
| http://purl.uniprot.org/citations/26439302 | http://purl.uniprot.org/core/author | "Deshpande A.J."xsd:string |
| http://purl.uniprot.org/citations/26439302 | http://purl.uniprot.org/core/author | "Krajewski K."xsd:string |
| http://purl.uniprot.org/citations/26439302 | http://purl.uniprot.org/core/author | "Krajewski K."xsd:string |