| http://purl.uniprot.org/citations/26465210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26465210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26465210 | http://www.w3.org/2000/01/rdf-schema#comment | "Phagocytosis is responsible for the elimination of particles of widely disparate sizes, from large fungi or effete cells to small bacteria. Though superficially similar, the molecular mechanisms involved differ: engulfment of large targets requires phosphoinositide 3-kinase (PI3K), while that of small ones does not. Here, we report that inactivation of Rac and Cdc42 at phagocytic cups is essential to complete internalization of large particles. Through a screen of 62 RhoGAP-family members, we demonstrate that ARHGAP12, ARHGAP25 and SH3BP1 are responsible for GTPase inactivation. Silencing these RhoGAPs impairs phagocytosis of large targets. The GAPs are recruited to large--but not small--phagocytic cups by products of PI3K, where they synergistically inactivate Rac and Cdc42. Remarkably, the prominent accumulation of phosphatidylinositol 3,4,5-trisphosphate characteristic of large-phagosome formation is less evident during phagocytosis of small targets, accounting for the contrasting RhoGAP distribution and the differential requirement for PI3K during phagocytosis of dissimilarly sized particles."xsd:string |
| http://purl.uniprot.org/citations/26465210 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms9623"xsd:string |
| http://purl.uniprot.org/citations/26465210 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms9623"xsd:string |
| http://purl.uniprot.org/citations/26465210 | http://purl.uniprot.org/core/author | "Bagshaw R.D."xsd:string |
| http://purl.uniprot.org/citations/26465210 | http://purl.uniprot.org/core/author | "Bagshaw R.D."xsd:string |
| http://purl.uniprot.org/citations/26465210 | http://purl.uniprot.org/core/author | "Collins R.F."xsd:string |
| http://purl.uniprot.org/citations/26465210 | http://purl.uniprot.org/core/author | "Collins R.F."xsd:string |
| http://purl.uniprot.org/citations/26465210 | http://purl.uniprot.org/core/author | "Fairn G.D."xsd:string |
| http://purl.uniprot.org/citations/26465210 | http://purl.uniprot.org/core/author | "Fairn G.D."xsd:string |
| http://purl.uniprot.org/citations/26465210 | http://purl.uniprot.org/core/author | "Freeman S.A."xsd:string |
| http://purl.uniprot.org/citations/26465210 | http://purl.uniprot.org/core/author | "Freeman S.A."xsd:string |
| http://purl.uniprot.org/citations/26465210 | http://purl.uniprot.org/core/author | "Grinstein S."xsd:string |
| http://purl.uniprot.org/citations/26465210 | http://purl.uniprot.org/core/author | "Grinstein S."xsd:string |
| http://purl.uniprot.org/citations/26465210 | http://purl.uniprot.org/core/author | "Pawson T."xsd:string |
| http://purl.uniprot.org/citations/26465210 | http://purl.uniprot.org/core/author | "Pawson T."xsd:string |
| http://purl.uniprot.org/citations/26465210 | http://purl.uniprot.org/core/author | "Schlam D."xsd:string |
| http://purl.uniprot.org/citations/26465210 | http://purl.uniprot.org/core/author | "Schlam D."xsd:string |
| http://purl.uniprot.org/citations/26465210 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26465210 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26465210 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/26465210 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/26465210 | http://purl.uniprot.org/core/pages | "8623"xsd:string |
| http://purl.uniprot.org/citations/26465210 | http://purl.uniprot.org/core/pages | "8623"xsd:string |