| http://purl.uniprot.org/citations/26479788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26479788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26479788 | http://www.w3.org/2000/01/rdf-schema#comment | "Enhancing the response to interferon could offer an immunological advantage to the host. In support of this concept, we used a modified form of the transcription factor STAT1 to achieve hyper-responsiveness to interferon without toxicity and markedly improve antiviral function in transgenic mice and transduced human cells. We found that the improvement depended on expression of a PARP9-DTX3L complex with distinct domains for interaction with STAT1 and for activity as an E3 ubiquitin ligase that acted on host histone H2BJ to promote interferon-stimulated gene expression and on viral 3C proteases to degrade these proteases via the immunoproteasome. Thus, PARP9-DTX3L acted on host and pathogen to achieve a double layer of immunity within a safe reserve in the interferon signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/26479788 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.3279"xsd:string |
| http://purl.uniprot.org/citations/26479788 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.3279"xsd:string |
| http://purl.uniprot.org/citations/26479788 | http://purl.uniprot.org/core/author | "Huang G."xsd:string |
| http://purl.uniprot.org/citations/26479788 | http://purl.uniprot.org/core/author | "Huang G."xsd:string |
| http://purl.uniprot.org/citations/26479788 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/26479788 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/26479788 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/26479788 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/26479788 | http://purl.uniprot.org/core/author | "Yu J."xsd:string |
| http://purl.uniprot.org/citations/26479788 | http://purl.uniprot.org/core/author | "Yu J."xsd:string |
| http://purl.uniprot.org/citations/26479788 | http://purl.uniprot.org/core/author | "Jin X."xsd:string |
| http://purl.uniprot.org/citations/26479788 | http://purl.uniprot.org/core/author | "Jin X."xsd:string |
| http://purl.uniprot.org/citations/26479788 | http://purl.uniprot.org/core/author | "Holtzman M.J."xsd:string |
| http://purl.uniprot.org/citations/26479788 | http://purl.uniprot.org/core/author | "Holtzman M.J."xsd:string |
| http://purl.uniprot.org/citations/26479788 | http://purl.uniprot.org/core/author | "Brett T.J."xsd:string |
| http://purl.uniprot.org/citations/26479788 | http://purl.uniprot.org/core/author | "Brett T.J."xsd:string |
| http://purl.uniprot.org/citations/26479788 | http://purl.uniprot.org/core/author | "Paessler S."xsd:string |
| http://purl.uniprot.org/citations/26479788 | http://purl.uniprot.org/core/author | "Paessler S."xsd:string |
| http://purl.uniprot.org/citations/26479788 | http://purl.uniprot.org/core/author | "Agapov E."xsd:string |
| http://purl.uniprot.org/citations/26479788 | http://purl.uniprot.org/core/author | "Agapov E."xsd:string |
| http://purl.uniprot.org/citations/26479788 | http://purl.uniprot.org/core/author | "Lawson T.G."xsd:string |
| http://purl.uniprot.org/citations/26479788 | http://purl.uniprot.org/core/author | "Lawson T.G."xsd:string |