| http://purl.uniprot.org/citations/26498453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26498453 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatitis C virus (HCV) E2 protein binds to CD81, which is a component of the B cell co-stimulatory complex. The E2-CD81 interaction leads to B cell proliferation, protein tyrosine phosphorylation and to the hypermutation of immunoglobulin genes. Epidemiological studies have reported a high prevalence of B cell non-Hodgkin lymphoma (NHL) in HCV-positive patients, suggesting a potential association between HCV and Epstein-Barr virus (EBV) in the genesis of B lymphocyte proliferative disorders. In the present study, in order to investigate the association between EBV and HCV in B cells, we created an in vitro EBV-induced B cell transformation model. CD81 was gradually overexpressed during transformation by EBV. B cells isolated from HCV-positive patients grew more rapidly and clumped together earlier than B cells isolated from healthy donors following EBV infection. Pre-stimulation of CD81 expressed by resting B cells with anti-CD81 monoclonal antibody (mAb) or HCV E2 accelerated the generation of lymphoblastoid cell lines (LCLs) by EBV infection. These cells proliferated prominently through the early expression of interleukin-10 and intracellular latent membrane protein (LMP)-l. By contrast, the overexpression of CD81 on EBV-transformed B cells by anti-CD81 mAb or HCV E2 protein induced apoptosis through reactive oxygen species (ROS)-mediated mitochondrial dysfunction. These results suggest that the engagement of CD81 expressed by B cells has differential effects on B cell fate (proliferation or apoptosis) according to EBV infection and the expression level of CD81."xsd:string |
| http://purl.uniprot.org/citations/26498453 | http://purl.org/dc/terms/identifier | "doi:10.3892/ijmm.2015.2372"xsd:string |
| http://purl.uniprot.org/citations/26498453 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/26498453 | http://purl.uniprot.org/core/author | "Lee H.K."xsd:string |
| http://purl.uniprot.org/citations/26498453 | http://purl.uniprot.org/core/author | "Kim Y.S."xsd:string |
| http://purl.uniprot.org/citations/26498453 | http://purl.uniprot.org/core/author | "Kim D."xsd:string |
| http://purl.uniprot.org/citations/26498453 | http://purl.uniprot.org/core/author | "Park S.G."xsd:string |
| http://purl.uniprot.org/citations/26498453 | http://purl.uniprot.org/core/author | "Lee Y.J."xsd:string |
| http://purl.uniprot.org/citations/26498453 | http://purl.uniprot.org/core/author | "Yoon S.H."xsd:string |
| http://purl.uniprot.org/citations/26498453 | http://purl.uniprot.org/core/author | "Park S.J."xsd:string |
| http://purl.uniprot.org/citations/26498453 | http://purl.uniprot.org/core/author | "Choi I.H."xsd:string |
| http://purl.uniprot.org/citations/26498453 | http://purl.uniprot.org/core/author | "Hur D.Y."xsd:string |
| http://purl.uniprot.org/citations/26498453 | http://purl.uniprot.org/core/author | "Park G.B."xsd:string |
| http://purl.uniprot.org/citations/26498453 | http://purl.uniprot.org/core/author | "Paeng S."xsd:string |
| http://purl.uniprot.org/citations/26498453 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26498453 | http://purl.uniprot.org/core/name | "Int J Mol Med"xsd:string |
| http://purl.uniprot.org/citations/26498453 | http://purl.uniprot.org/core/pages | "1464-1478"xsd:string |
| http://purl.uniprot.org/citations/26498453 | http://purl.uniprot.org/core/title | "Pre-stimulation of CD81 expression by resting B cells increases proliferation following EBV infection, but the overexpression of CD81 induces the apoptosis of EBV-transformed B cells."xsd:string |
| http://purl.uniprot.org/citations/26498453 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/26498453 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26498453 |
| http://purl.uniprot.org/citations/26498453 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26498453 |
| http://purl.uniprot.org/uniprot/#_E9PJK1-mappedCitation-26498453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26498453 |
| http://purl.uniprot.org/uniprot/#_P60033-mappedCitation-26498453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26498453 |
| http://purl.uniprot.org/uniprot/#_Q59FS9-mappedCitation-26498453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26498453 |