| http://purl.uniprot.org/citations/26507128 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26507128 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26507128 | http://www.w3.org/2000/01/rdf-schema#comment | "Modulation of TCR signaling upon ligand binding is achieved by changes in the equilibrium between TCR degradation, recycling and synthesis; surprisingly, the molecular mechanism of such an important process is not fully understood. Here, we describe the role of a new player in the mediation of TCR degradation: the endocytic adaptor Numb. Our data show that Numb inhibition leads to abnormal intracellular distribution and defective TCR degradation in mature T lymphocytes. In addition, we find that Numb simultaneously binds to both Cbl and a site within CD3ε that overlaps with the Nck binding site. As a result, Cbl couples specifically to the CD3ε chain to mediate TCR degradation. The present study unveils a novel role of Numb that lies at the heart of TCR signaling initiation and termination."xsd:string |
| http://purl.uniprot.org/citations/26507128 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxv060"xsd:string |
| http://purl.uniprot.org/citations/26507128 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxv060"xsd:string |
| http://purl.uniprot.org/citations/26507128 | http://purl.uniprot.org/core/author | "Leon J."xsd:string |
| http://purl.uniprot.org/citations/26507128 | http://purl.uniprot.org/core/author | "Leon J."xsd:string |
| http://purl.uniprot.org/citations/26507128 | http://purl.uniprot.org/core/author | "Alarcon B."xsd:string |
| http://purl.uniprot.org/citations/26507128 | http://purl.uniprot.org/core/author | "Alarcon B."xsd:string |
| http://purl.uniprot.org/citations/26507128 | http://purl.uniprot.org/core/author | "Bretones G."xsd:string |
| http://purl.uniprot.org/citations/26507128 | http://purl.uniprot.org/core/author | "Bretones G."xsd:string |
| http://purl.uniprot.org/citations/26507128 | http://purl.uniprot.org/core/author | "Screpanti I."xsd:string |
| http://purl.uniprot.org/citations/26507128 | http://purl.uniprot.org/core/author | "Screpanti I."xsd:string |
| http://purl.uniprot.org/citations/26507128 | http://purl.uniprot.org/core/author | "Borroto A."xsd:string |
| http://purl.uniprot.org/citations/26507128 | http://purl.uniprot.org/core/author | "Borroto A."xsd:string |
| http://purl.uniprot.org/citations/26507128 | http://purl.uniprot.org/core/author | "Canelles M."xsd:string |
| http://purl.uniprot.org/citations/26507128 | http://purl.uniprot.org/core/author | "Canelles M."xsd:string |
| http://purl.uniprot.org/citations/26507128 | http://purl.uniprot.org/core/author | "Caraballo M."xsd:string |
| http://purl.uniprot.org/citations/26507128 | http://purl.uniprot.org/core/author | "Caraballo M."xsd:string |
| http://purl.uniprot.org/citations/26507128 | http://purl.uniprot.org/core/author | "Jimenez Teja D."xsd:string |
| http://purl.uniprot.org/citations/26507128 | http://purl.uniprot.org/core/author | "Jimenez Teja D."xsd:string |
| http://purl.uniprot.org/citations/26507128 | http://purl.uniprot.org/core/author | "Martin-Blanco N."xsd:string |
| http://purl.uniprot.org/citations/26507128 | http://purl.uniprot.org/core/author | "Martin-Blanco N."xsd:string |
| http://purl.uniprot.org/citations/26507128 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26507128 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |