| http://purl.uniprot.org/citations/26577029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26577029 | http://www.w3.org/2000/01/rdf-schema#comment | "In the pupal stage, the fly body undergoes extensive metamorphic remodeling, in which programmed cell death plays a critical role. We studied two of the constituent processes in this remodeling, salivary gland degeneration and breakdown of the eclosion muscle, which are triggered by an increase and a decrease in the circulating steroid hormone ecdysone at the start and end of metamorphosis, respectively. We found that knockdown of zeste (z), a gene encoding a sequence-specific DNA-binding protein implicated in transvection, in salivary gland cells advances the initiation of their degeneration, whereas z knockdown in neurons delays muscle breakdown. We further showed that knockdown of an ecdysone-inducible gene, E74, retards salivary gland degeneration with little effect on eclosion muscle breakdown. We propose that Z tunes the sensitivity of ecdysone targets to this hormone in order to ensure a high safety margin so that the cell death program will be activated when the ecdysone titer is at a sufficiently high level that is reached only at a defined stage during metamorphosis."xsd:string |
| http://purl.uniprot.org/citations/26577029 | http://purl.org/dc/terms/identifier | "doi:10.3109/01677063.2015.1098638"xsd:string |
| http://purl.uniprot.org/citations/26577029 | http://purl.uniprot.org/core/author | "Goto T."xsd:string |
| http://purl.uniprot.org/citations/26577029 | http://purl.uniprot.org/core/author | "Ito H."xsd:string |
| http://purl.uniprot.org/citations/26577029 | http://purl.uniprot.org/core/author | "Sato K."xsd:string |
| http://purl.uniprot.org/citations/26577029 | http://purl.uniprot.org/core/author | "Sone H."xsd:string |
| http://purl.uniprot.org/citations/26577029 | http://purl.uniprot.org/core/author | "Yamamoto D."xsd:string |
| http://purl.uniprot.org/citations/26577029 | http://purl.uniprot.org/core/author | "Koganezawa M."xsd:string |
| http://purl.uniprot.org/citations/26577029 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26577029 | http://purl.uniprot.org/core/name | "J Neurogenet"xsd:string |
| http://purl.uniprot.org/citations/26577029 | http://purl.uniprot.org/core/pages | "169-173"xsd:string |
| http://purl.uniprot.org/citations/26577029 | http://purl.uniprot.org/core/title | "Zeste tunes the timing of ecdysone actions in triggering programmed tissue degeneration in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/26577029 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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