| http://purl.uniprot.org/citations/26602187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26602187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26602187 | http://www.w3.org/2000/01/rdf-schema#comment | "Targeting the PD-1/PD-L1 immunologic checkpoint with monoclonal antibodies has recently provided breakthrough progress in the treatment of melanoma, non-small cell lung cancer, and other types of cancer. Small-molecule drugs interfering with this pathway are highly awaited, but their development is hindered by insufficient structural information. This study reveals the molecular details of the human PD-1/PD-L1 interaction based on an X-ray structure of the complex. First, it is shown that the ligand binding to human PD-1 is associated with significant plasticity within the receptor. Second, a detailed molecular map of the interaction surface is provided, allowing definition of the regions within both interacting partners that may likely be targeted by small molecules."xsd:string |
| http://purl.uniprot.org/citations/26602187 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2015.09.010"xsd:string |
| http://purl.uniprot.org/citations/26602187 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2015.09.010"xsd:string |
| http://purl.uniprot.org/citations/26602187 | http://purl.uniprot.org/core/author | "Holak T.A."xsd:string |
| http://purl.uniprot.org/citations/26602187 | http://purl.uniprot.org/core/author | "Holak T.A."xsd:string |
| http://purl.uniprot.org/citations/26602187 | http://purl.uniprot.org/core/author | "Dubin G."xsd:string |
| http://purl.uniprot.org/citations/26602187 | http://purl.uniprot.org/core/author | "Dubin G."xsd:string |
| http://purl.uniprot.org/citations/26602187 | http://purl.uniprot.org/core/author | "Golik P."xsd:string |
| http://purl.uniprot.org/citations/26602187 | http://purl.uniprot.org/core/author | "Golik P."xsd:string |
| http://purl.uniprot.org/citations/26602187 | http://purl.uniprot.org/core/author | "Zak K.M."xsd:string |
| http://purl.uniprot.org/citations/26602187 | http://purl.uniprot.org/core/author | "Zak K.M."xsd:string |
| http://purl.uniprot.org/citations/26602187 | http://purl.uniprot.org/core/author | "Guzik K."xsd:string |
| http://purl.uniprot.org/citations/26602187 | http://purl.uniprot.org/core/author | "Guzik K."xsd:string |
| http://purl.uniprot.org/citations/26602187 | http://purl.uniprot.org/core/author | "Domling A."xsd:string |
| http://purl.uniprot.org/citations/26602187 | http://purl.uniprot.org/core/author | "Domling A."xsd:string |
| http://purl.uniprot.org/citations/26602187 | http://purl.uniprot.org/core/author | "Kitel R."xsd:string |
| http://purl.uniprot.org/citations/26602187 | http://purl.uniprot.org/core/author | "Kitel R."xsd:string |
| http://purl.uniprot.org/citations/26602187 | http://purl.uniprot.org/core/author | "Musielak B."xsd:string |
| http://purl.uniprot.org/citations/26602187 | http://purl.uniprot.org/core/author | "Musielak B."xsd:string |
| http://purl.uniprot.org/citations/26602187 | http://purl.uniprot.org/core/author | "Przetocka S."xsd:string |
| http://purl.uniprot.org/citations/26602187 | http://purl.uniprot.org/core/author | "Przetocka S."xsd:string |
| http://purl.uniprot.org/citations/26602187 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26602187 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |