| http://purl.uniprot.org/citations/26869717 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26869717 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26869717 | http://www.w3.org/2000/01/rdf-schema#comment | "Peptide loading of major histocompatibility complex class I (MHC-I) molecules is central to antigen presentation, self-tolerance, and CD8(+) T-cell activation. TAP binding protein, related (TAPBPR), a widely expressed tapasin homolog, is not part of the classical MHC-I peptide-loading complex (PLC). Using recombinant MHC-I molecules, we show that TAPBPR binds HLA-A*02:01 and several other MHC-I molecules that are either peptide-free or loaded with low-affinity peptides. Fluorescence polarization experiments establish that TAPBPR augments peptide binding by MHC-I. The TAPBPR/MHC-I interaction is reversed by specific peptides, related to their affinity. Mutational and small-angle X-ray scattering (SAXS) studies confirm the structural similarities of TAPBPR with tapasin. These results support a role of TAPBPR in stabilizing peptide-receptive conformation(s) of MHC-I, permitting peptide editing."xsd:string |
| http://purl.uniprot.org/citations/26869717 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1519894113"xsd:string |
| http://purl.uniprot.org/citations/26869717 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1519894113"xsd:string |
| http://purl.uniprot.org/citations/26869717 | http://purl.uniprot.org/core/author | "Jiang J."xsd:string |
| http://purl.uniprot.org/citations/26869717 | http://purl.uniprot.org/core/author | "Jiang J."xsd:string |
| http://purl.uniprot.org/citations/26869717 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
| http://purl.uniprot.org/citations/26869717 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
| http://purl.uniprot.org/citations/26869717 | http://purl.uniprot.org/core/author | "Natarajan K."xsd:string |
| http://purl.uniprot.org/citations/26869717 | http://purl.uniprot.org/core/author | "Natarajan K."xsd:string |
| http://purl.uniprot.org/citations/26869717 | http://purl.uniprot.org/core/author | "Schuck P."xsd:string |
| http://purl.uniprot.org/citations/26869717 | http://purl.uniprot.org/core/author | "Schuck P."xsd:string |
| http://purl.uniprot.org/citations/26869717 | http://purl.uniprot.org/core/author | "Dolan M.A."xsd:string |
| http://purl.uniprot.org/citations/26869717 | http://purl.uniprot.org/core/author | "Dolan M.A."xsd:string |
| http://purl.uniprot.org/citations/26869717 | http://purl.uniprot.org/core/author | "Norcross M.A."xsd:string |
| http://purl.uniprot.org/citations/26869717 | http://purl.uniprot.org/core/author | "Norcross M.A."xsd:string |
| http://purl.uniprot.org/citations/26869717 | http://purl.uniprot.org/core/author | "Margulies D.H."xsd:string |
| http://purl.uniprot.org/citations/26869717 | http://purl.uniprot.org/core/author | "Margulies D.H."xsd:string |
| http://purl.uniprot.org/citations/26869717 | http://purl.uniprot.org/core/author | "Boyd L.F."xsd:string |
| http://purl.uniprot.org/citations/26869717 | http://purl.uniprot.org/core/author | "Boyd L.F."xsd:string |
| http://purl.uniprot.org/citations/26869717 | http://purl.uniprot.org/core/author | "Hildebrand W."xsd:string |
| http://purl.uniprot.org/citations/26869717 | http://purl.uniprot.org/core/author | "Hildebrand W."xsd:string |
| http://purl.uniprot.org/citations/26869717 | http://purl.uniprot.org/core/author | "Mage M.G."xsd:string |
| http://purl.uniprot.org/citations/26869717 | http://purl.uniprot.org/core/author | "Mage M.G."xsd:string |