| http://purl.uniprot.org/citations/27211601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27211601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27211601 | http://www.w3.org/2000/01/rdf-schema#comment | "Promyelocytic leukemia nuclear bodies (PML-NBs) are PML-based nuclear structures that regulate various cellular processes. SUMOylation, the process of covalently conjugating small ubiquitin-like modifiers (SUMOs), is required for both the formation and the disruption of PML-NBs. However, detailed mechanisms of how SUMOylation regulates these processes remain unknown. Here we report that SUMO5, a novel SUMO variant, mediates the growth and disruption of PML-NBs. PolySUMO5 conjugation of PML at lysine 160 facilitates recruitment of PML-NB components, which enlarges PML-NBs. SUMO5 also increases polySUMO2/3 conjugation of PML, resulting in RNF4-mediated disruption of PML-NBs. The acute promyelocytic leukemia oncoprotein PML-RARα blocks SUMO5 conjugation of PML, causing cytoplasmic displacement of PML and disruption of PML-NBs. Our work not only identifies a new member of the SUMO family but also reveals the mechanistic basis of the PML-NB life cycle in human cells."xsd:string |
| http://purl.uniprot.org/citations/27211601 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep26509"xsd:string |
| http://purl.uniprot.org/citations/27211601 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep26509"xsd:string |
| http://purl.uniprot.org/citations/27211601 | http://purl.uniprot.org/core/author | "Lee C.C."xsd:string |
| http://purl.uniprot.org/citations/27211601 | http://purl.uniprot.org/core/author | "Lee C.C."xsd:string |
| http://purl.uniprot.org/citations/27211601 | http://purl.uniprot.org/core/author | "Lai C.C."xsd:string |
| http://purl.uniprot.org/citations/27211601 | http://purl.uniprot.org/core/author | "Lai C.C."xsd:string |
| http://purl.uniprot.org/citations/27211601 | http://purl.uniprot.org/core/author | "Liang Y.C."xsd:string |
| http://purl.uniprot.org/citations/27211601 | http://purl.uniprot.org/core/author | "Liang Y.C."xsd:string |
| http://purl.uniprot.org/citations/27211601 | http://purl.uniprot.org/core/author | "Schmitz M.L."xsd:string |
| http://purl.uniprot.org/citations/27211601 | http://purl.uniprot.org/core/author | "Schmitz M.L."xsd:string |
| http://purl.uniprot.org/citations/27211601 | http://purl.uniprot.org/core/author | "Yang W.M."xsd:string |
| http://purl.uniprot.org/citations/27211601 | http://purl.uniprot.org/core/author | "Yang W.M."xsd:string |
| http://purl.uniprot.org/citations/27211601 | http://purl.uniprot.org/core/author | "Yao Y.L."xsd:string |
| http://purl.uniprot.org/citations/27211601 | http://purl.uniprot.org/core/author | "Yao Y.L."xsd:string |
| http://purl.uniprot.org/citations/27211601 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27211601 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27211601 | http://purl.uniprot.org/core/name | "Sci. Rep."xsd:string |
| http://purl.uniprot.org/citations/27211601 | http://purl.uniprot.org/core/name | "Sci. Rep."xsd:string |
| http://purl.uniprot.org/citations/27211601 | http://purl.uniprot.org/core/pages | "26509"xsd:string |
| http://purl.uniprot.org/citations/27211601 | http://purl.uniprot.org/core/pages | "26509"xsd:string |
| http://purl.uniprot.org/citations/27211601 | http://purl.uniprot.org/core/title | "SUMO5, a novel poly-sumo isoform, regulates pml nuclear bodies."xsd:string |
| http://purl.uniprot.org/citations/27211601 | http://purl.uniprot.org/core/title | "SUMO5, a novel poly-sumo isoform, regulates pml nuclear bodies."xsd:string |