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http://purl.uniprot.org/citations/27302953http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27302953http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27302953http://www.w3.org/2000/01/rdf-schema#comment"Type I IFNs are key cytokines mediating innate antiviral immunity. cGMP-AMP synthase, ritinoic acid-inducible protein 1 (RIG-I)-like receptors, and Toll-like receptors recognize microbial double-stranded (ds)DNA, dsRNA, and LPS to induce the expression of type I IFNs. These signaling pathways converge at the recruitment and activation of the transcription factor IRF-3 (IFN regulatory factor 3). The adaptor proteins STING (stimulator of IFN genes), MAVS (mitochondrial antiviral signaling), and TRIF (TIR domain-containing adaptor inducing IFN-β) mediate the recruitment of IRF-3 through a conserved pLxIS motif. Here we show that the pLxIS motif of phosphorylated STING, MAVS, and TRIF binds to IRF-3 in a similar manner, whereas residues upstream of the motif confer specificity. The structure of the IRF-3 phosphomimetic mutant S386/396E bound to the cAMP response element binding protein (CREB)-binding protein reveals that the pLxIS motif also mediates IRF-3 dimerization and activation. Moreover, rotavirus NSP1 (nonstructural protein 1) employs a pLxIS motif to target IRF-3 for degradation, but phosphorylation of NSP1 is not required for its activity. These results suggest a concerted mechanism for the recruitment and activation of IRF-3 that can be subverted by viral proteins to evade innate immune responses."xsd:string
http://purl.uniprot.org/citations/27302953http://purl.org/dc/terms/identifier"doi:10.1073/pnas.1603269113"xsd:string
http://purl.uniprot.org/citations/27302953http://purl.org/dc/terms/identifier"doi:10.1073/pnas.1603269113"xsd:string
http://purl.uniprot.org/citations/27302953http://purl.uniprot.org/core/author"Du F."xsd:string
http://purl.uniprot.org/citations/27302953http://purl.uniprot.org/core/author"Du F."xsd:string
http://purl.uniprot.org/citations/27302953http://purl.uniprot.org/core/author"Gao X."xsd:string
http://purl.uniprot.org/citations/27302953http://purl.uniprot.org/core/author"Gao X."xsd:string
http://purl.uniprot.org/citations/27302953http://purl.uniprot.org/core/author"Li P."xsd:string
http://purl.uniprot.org/citations/27302953http://purl.uniprot.org/core/author"Li P."xsd:string
http://purl.uniprot.org/citations/27302953http://purl.uniprot.org/core/author"Sankaran B."xsd:string
http://purl.uniprot.org/citations/27302953http://purl.uniprot.org/core/author"Sankaran B."xsd:string
http://purl.uniprot.org/citations/27302953http://purl.uniprot.org/core/author"Zhao B."xsd:string
http://purl.uniprot.org/citations/27302953http://purl.uniprot.org/core/author"Zhao B."xsd:string
http://purl.uniprot.org/citations/27302953http://purl.uniprot.org/core/author"Shu C."xsd:string
http://purl.uniprot.org/citations/27302953http://purl.uniprot.org/core/author"Shu C."xsd:string
http://purl.uniprot.org/citations/27302953http://purl.uniprot.org/core/author"Herr A.B."xsd:string
http://purl.uniprot.org/citations/27302953http://purl.uniprot.org/core/author"Herr A.B."xsd:string
http://purl.uniprot.org/citations/27302953http://purl.uniprot.org/core/author"Ji J.Y."xsd:string
http://purl.uniprot.org/citations/27302953http://purl.uniprot.org/core/author"Ji J.Y."xsd:string
http://purl.uniprot.org/citations/27302953http://purl.uniprot.org/core/author"Shelton C.L."xsd:string
http://purl.uniprot.org/citations/27302953http://purl.uniprot.org/core/author"Shelton C.L."xsd:string
http://purl.uniprot.org/citations/27302953http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/27302953http://purl.uniprot.org/core/date"2016"xsd:gYear
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