| http://purl.uniprot.org/citations/27385586 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27385586 | http://www.w3.org/2000/01/rdf-schema#comment | "Endosomal sorting is a highly orchestrated cellular process. Retromer is a heterotrimeric complex that associates with endosomal membranes and facilitates the retrograde sorting of multiple receptors, including the cation-independent mannose 6-phosphate receptor for lysosomal enzymes. The cycling of retromer on and off the endosomal membrane is regulated by a network of retromer-interacting proteins. Here, we find that Parkinson disease-associated Vps35 variant, R524W, but not P316S, is a loss-of-function mutation as marked by a reduced association with this regulatory network and dysregulation of endosomal receptor sorting. Expression of Vps35 R524W-containing retromer results in the accumulation of intracellular α-synuclein-positive aggregates, a hallmark of Parkinson disease. Overall, the Vps35 R524W-containing retromer has a decreased endosomal association, which can be partially rescued by R55, a small molecule previously shown to stabilize the retromer complex, supporting the potential for future targeting of the retromer complex in the treatment of Parkinson disease."xsd:string |
| http://purl.uniprot.org/citations/27385586 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m115.703157"xsd:string |
| http://purl.uniprot.org/citations/27385586 | http://purl.uniprot.org/core/author | "Teasdale R.D."xsd:string |
| http://purl.uniprot.org/citations/27385586 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/27385586 | http://purl.uniprot.org/core/author | "Collins B.M."xsd:string |
| http://purl.uniprot.org/citations/27385586 | http://purl.uniprot.org/core/author | "Parton R.G."xsd:string |
| http://purl.uniprot.org/citations/27385586 | http://purl.uniprot.org/core/author | "Bugarcic A."xsd:string |
| http://purl.uniprot.org/citations/27385586 | http://purl.uniprot.org/core/author | "Follett J."xsd:string |
| http://purl.uniprot.org/citations/27385586 | http://purl.uniprot.org/core/author | "Norwood S.J."xsd:string |
| http://purl.uniprot.org/citations/27385586 | http://purl.uniprot.org/core/author | "Ariotti N."xsd:string |
| http://purl.uniprot.org/citations/27385586 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27385586 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/27385586 | http://purl.uniprot.org/core/pages | "18283-18298"xsd:string |
| http://purl.uniprot.org/citations/27385586 | http://purl.uniprot.org/core/title | "Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces alpha-Synuclein Aggregation."xsd:string |
| http://purl.uniprot.org/citations/27385586 | http://purl.uniprot.org/core/volume | "291"xsd:string |
| http://purl.uniprot.org/citations/27385586 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27385586 |
| http://purl.uniprot.org/citations/27385586 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27385586 |
| http://purl.uniprot.org/uniprot/P20645#attribution-AC90BF03B83F779B547A14387B507EE1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27385586 |
| http://purl.uniprot.org/uniprot/P51149#attribution-AC90BF03B83F779B547A14387B507EE1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27385586 |
| http://purl.uniprot.org/uniprot/Q96L92#attribution-6CE57E2BB60F503D452E8B461FC48BDF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27385586 |
| http://purl.uniprot.org/uniprot/Q92609#attribution-AC90BF03B83F779B547A14387B507EE1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27385586 |
| http://purl.uniprot.org/uniprot/O75436#attribution-C6DE944FED8EF8880D90B75A366013A2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27385586 |
| http://purl.uniprot.org/uniprot/Q96QK1#attribution-C6DE944FED8EF8880D90B75A366013A2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27385586 |
| http://purl.uniprot.org/uniprot/Q9UBQ0#attribution-C6DE944FED8EF8880D90B75A366013A2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27385586 |