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http://purl.uniprot.org/citations/27395777http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27395777http://www.w3.org/2000/01/rdf-schema#comment"

Background/aims

Hypoxia induces angiogenesis while hyperoxia promotes vasoregression in the retina. We investigated herein the effect of prolonged hyperoxia on retinal angiogenesis and the underlying mechanism in an oxygen-induced retinopathy (OIR) model.

Methods

Vascular morphology was quantified in whole-mount retina from the mice subjected to the conventional OIR model (c-OIR) or the OIR model with prolonged hyperoxia (p-OIR). Expressions of genes related to angiogenesis were determined by real-time PCR.

Results

p-OIR retinas showed few intraretinal neovascular tufts at the border of avascular zones, lacking preretinal neovascularization, whereas c-OIR retinas had numerous preretinal neovascularizations. p-OIR retinas demonstrated outgrowth of capillaries in the deep layers despite persistent hyperoxia and possess a larger avascular zone compared with the c-OIR retinas. The capillaries in the p-OIR retinas were well-formed in contrast to those in the c-OIR retinas. p-OIR retinas expressed significantly higher TNFα (∼4 fold) than c-OIR retinas. The expression of vascular endothelial growth factor, Erythropoietin, Angiopoietin 1 and 2 remained unchanged.

Conclusion

Our data demonstrate that TNFα transcription is increased in hyperoxia-promoted retinal angiogenesis, implicating it, in association with low VEGF levels, as a possible proponent in retinal angiogenesis under hyperoxia."xsd:string
http://purl.uniprot.org/citations/27395777http://purl.org/dc/terms/identifier"doi:10.1159/000445649"xsd:string
http://purl.uniprot.org/citations/27395777http://purl.uniprot.org/core/author"Feng Y."xsd:string
http://purl.uniprot.org/citations/27395777http://purl.uniprot.org/core/author"Lin J."xsd:string
http://purl.uniprot.org/citations/27395777http://purl.uniprot.org/core/author"Chatterjee A."xsd:string
http://purl.uniprot.org/citations/27395777http://purl.uniprot.org/core/author"Wang Y."xsd:string
http://purl.uniprot.org/citations/27395777http://purl.uniprot.org/core/author"Gross S."xsd:string
http://purl.uniprot.org/citations/27395777http://purl.uniprot.org/core/author"Hammes H.P."xsd:string
http://purl.uniprot.org/citations/27395777http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/27395777http://purl.uniprot.org/core/name"Cell Physiol Biochem"xsd:string
http://purl.uniprot.org/citations/27395777http://purl.uniprot.org/core/pages"573-583"xsd:string
http://purl.uniprot.org/citations/27395777http://purl.uniprot.org/core/title"Transcription of Inflammatory Cytokine TNFalpha is Upregulated in Retinal Angiogenesis under Hyperoxia."xsd:string
http://purl.uniprot.org/citations/27395777http://purl.uniprot.org/core/volume"39"xsd:string
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