| http://purl.uniprot.org/citations/27462908 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27462908 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27462908 | http://www.w3.org/2000/01/rdf-schema#comment | "A heavy-ion beam has been recognized as an effective mutagen for plant breeding and applied to the many kinds of crops including rice. In contrast with X-ray or γ-ray, the heavy-ion beam is characterized by a high linear energy transfer (LET). LET is an important factor affecting several aspects of the irradiation effect, e.g. cell survival and mutation frequency, making the heavy-ion beam an effective mutagen. To study the mechanisms behind LET-dependent effects, expression profiling was performed after heavy-ion beam irradiation of imbibed rice seeds. Array-based experiments at three time points (0.5, 1, 2 h after the irradiation) revealed that the number of up- or down-regulated genes was highest 2 h after irradiation. Array-based experiments with four different LETs at 2 h after irradiation identified LET-independent regulated genes that were up/down-regulated regardless of the value of LET; LET-dependent regulated genes, whose expression level increased with the rise of LET value, were also identified. Gene ontology (GO) analysis of LET-independent up-regulated genes showed that some GO terms were commonly enriched, both 2 hours and 3 weeks after irradiation. GO terms enriched in LET-dependent regulated genes implied that some factor regulates genes that have kinase activity or DNA-binding activity in cooperation with the ATM gene. Of the LET-dependent up-regulated genes, OsPARP3 and OsPCNA were identified, which are involved in DNA repair pathways. This indicates that the Ku-independent alternative non-homologous end-joining pathway may contribute to repairing complex DNA legions induced by high-LET irradiation. These findings may clarify various LET-dependent responses in rice."xsd:string |
| http://purl.uniprot.org/citations/27462908 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0160061"xsd:string |
| http://purl.uniprot.org/citations/27462908 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0160061"xsd:string |
| http://purl.uniprot.org/citations/27462908 | http://purl.uniprot.org/core/author | "Abe T."xsd:string |
| http://purl.uniprot.org/citations/27462908 | http://purl.uniprot.org/core/author | "Abe T."xsd:string |
| http://purl.uniprot.org/citations/27462908 | http://purl.uniprot.org/core/author | "Ishii K."xsd:string |
| http://purl.uniprot.org/citations/27462908 | http://purl.uniprot.org/core/author | "Ishii K."xsd:string |
| http://purl.uniprot.org/citations/27462908 | http://purl.uniprot.org/core/author | "Hayashi Y."xsd:string |
| http://purl.uniprot.org/citations/27462908 | http://purl.uniprot.org/core/author | "Hayashi Y."xsd:string |
| http://purl.uniprot.org/citations/27462908 | http://purl.uniprot.org/core/author | "Ikeda T."xsd:string |
| http://purl.uniprot.org/citations/27462908 | http://purl.uniprot.org/core/author | "Ikeda T."xsd:string |
| http://purl.uniprot.org/citations/27462908 | http://purl.uniprot.org/core/author | "Nagamura Y."xsd:string |
| http://purl.uniprot.org/citations/27462908 | http://purl.uniprot.org/core/author | "Nagamura Y."xsd:string |
| http://purl.uniprot.org/citations/27462908 | http://purl.uniprot.org/core/author | "Usuda S."xsd:string |
| http://purl.uniprot.org/citations/27462908 | http://purl.uniprot.org/core/author | "Usuda S."xsd:string |
| http://purl.uniprot.org/citations/27462908 | http://purl.uniprot.org/core/author | "Hirano T."xsd:string |
| http://purl.uniprot.org/citations/27462908 | http://purl.uniprot.org/core/author | "Hirano T."xsd:string |
| http://purl.uniprot.org/citations/27462908 | http://purl.uniprot.org/core/author | "Morita R."xsd:string |
| http://purl.uniprot.org/citations/27462908 | http://purl.uniprot.org/core/author | "Morita R."xsd:string |
| http://purl.uniprot.org/citations/27462908 | http://purl.uniprot.org/core/author | "Motoyama R."xsd:string |
| http://purl.uniprot.org/citations/27462908 | http://purl.uniprot.org/core/author | "Motoyama R."xsd:string |
| http://purl.uniprot.org/citations/27462908 | http://purl.uniprot.org/core/author | "Kazama Y."xsd:string |
| http://purl.uniprot.org/citations/27462908 | http://purl.uniprot.org/core/author | "Kazama Y."xsd:string |