| http://purl.uniprot.org/citations/27492130 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27492130 | http://www.w3.org/2000/01/rdf-schema#comment | "Cold- and β3-adrenoceptor agonist-induced sympathetic activation leads to angiogenesis and UCP1-dependent thermogenesis in mouse brown and white adipose tissues. Here we show that endothelial production of PDGF-CC during white adipose tissue (WAT) angiogenesis regulates WAT browning. We find that genetic deletion of endothelial VEGFR2, knockout of the Pdgf-c gene or pharmacological blockade of PDGFR-α impair the WAT-beige transition. We further show that PDGF-CC stimulation upregulates UCP1 expression and acquisition of a beige phenotype in differentiated mouse WAT-PDGFR-α(+) progenitor cells, as well as in human WAT-PDGFR-α(+) adipocytes, supporting the physiological relevance of our findings. Our data reveal a paracrine mechanism by which angiogenic endothelial cells modulate adipocyte metabolism, which may provide new targets for the treatment of obesity and related metabolic diseases."xsd:string |
| http://purl.uniprot.org/citations/27492130 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms12152"xsd:string |
| http://purl.uniprot.org/citations/27492130 | http://purl.uniprot.org/core/author | "Cao Y."xsd:string |
| http://purl.uniprot.org/citations/27492130 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/27492130 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/27492130 | http://purl.uniprot.org/core/author | "Nakamura M."xsd:string |
| http://purl.uniprot.org/citations/27492130 | http://purl.uniprot.org/core/author | "Sun M."xsd:string |
| http://purl.uniprot.org/citations/27492130 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/27492130 | http://purl.uniprot.org/core/author | "Seki T."xsd:string |
| http://purl.uniprot.org/citations/27492130 | http://purl.uniprot.org/core/author | "Lim S."xsd:string |
| http://purl.uniprot.org/citations/27492130 | http://purl.uniprot.org/core/author | "Fischer C."xsd:string |
| http://purl.uniprot.org/citations/27492130 | http://purl.uniprot.org/core/author | "Samani N.J."xsd:string |
| http://purl.uniprot.org/citations/27492130 | http://purl.uniprot.org/core/author | "Hosaka K."xsd:string |
| http://purl.uniprot.org/citations/27492130 | http://purl.uniprot.org/core/author | "Iwamoto H."xsd:string |
| http://purl.uniprot.org/citations/27492130 | http://purl.uniprot.org/core/author | "Andersson P."xsd:string |
| http://purl.uniprot.org/citations/27492130 | http://purl.uniprot.org/core/author | "Yla-Herttuala S."xsd:string |
| http://purl.uniprot.org/citations/27492130 | http://purl.uniprot.org/core/author | "Honek J."xsd:string |
| http://purl.uniprot.org/citations/27492130 | http://purl.uniprot.org/core/author | "Naslund E."xsd:string |
| http://purl.uniprot.org/citations/27492130 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27492130 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/27492130 | http://purl.uniprot.org/core/pages | "12152"xsd:string |
| http://purl.uniprot.org/citations/27492130 | http://purl.uniprot.org/core/title | "Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat."xsd:string |
| http://purl.uniprot.org/citations/27492130 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27492130 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27492130 |