| http://purl.uniprot.org/citations/27617429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27617429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27617429 | http://www.w3.org/2000/01/rdf-schema#comment | "Insulins in the venom of certain fish-hunting cone snails facilitate prey capture by rapidly inducing hypoglycemic shock. One such insulin, Conus geographus G1 (Con-Ins G1), is the smallest known insulin found in nature and lacks the C-terminal segment of the B chain that, in human insulin, mediates engagement of the insulin receptor and assembly of the hormone's hexameric storage form. Removal of this segment (residues B23-B30) in human insulin results in substantial loss of receptor affinity. Here, we found that Con-Ins G1 is monomeric, strongly binds the human insulin receptor and activates receptor signaling. Con-Ins G1 thus is a naturally occurring B-chain-minimized mimetic of human insulin. Our crystal structure of Con-Ins G1 reveals a tertiary structure highly similar to that of human insulin and indicates how Con-Ins G1's lack of an equivalent to the key receptor-engaging residue PheB24 is mitigated. These findings may facilitate efforts to design ultrarapid-acting therapeutic insulins."xsd:string |
| http://purl.uniprot.org/citations/27617429 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.3292"xsd:string |
| http://purl.uniprot.org/citations/27617429 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.3292"xsd:string |
| http://purl.uniprot.org/citations/27617429 | http://purl.uniprot.org/core/author | "Miller C."xsd:string |
| http://purl.uniprot.org/citations/27617429 | http://purl.uniprot.org/core/author | "Miller C."xsd:string |
| http://purl.uniprot.org/citations/27617429 | http://purl.uniprot.org/core/author | "Lawrence M.C."xsd:string |
| http://purl.uniprot.org/citations/27617429 | http://purl.uniprot.org/core/author | "Lawrence M.C."xsd:string |
| http://purl.uniprot.org/citations/27617429 | http://purl.uniprot.org/core/author | "Norton R.S."xsd:string |
| http://purl.uniprot.org/citations/27617429 | http://purl.uniprot.org/core/author | "Norton R.S."xsd:string |
| http://purl.uniprot.org/citations/27617429 | http://purl.uniprot.org/core/author | "Smith B.J."xsd:string |
| http://purl.uniprot.org/citations/27617429 | http://purl.uniprot.org/core/author | "Smith B.J."xsd:string |
| http://purl.uniprot.org/citations/27617429 | http://purl.uniprot.org/core/author | "Smith N.A."xsd:string |
| http://purl.uniprot.org/citations/27617429 | http://purl.uniprot.org/core/author | "Smith N.A."xsd:string |
| http://purl.uniprot.org/citations/27617429 | http://purl.uniprot.org/core/author | "MacRaild C.A."xsd:string |
| http://purl.uniprot.org/citations/27617429 | http://purl.uniprot.org/core/author | "MacRaild C.A."xsd:string |
| http://purl.uniprot.org/citations/27617429 | http://purl.uniprot.org/core/author | "Olivera B.M."xsd:string |
| http://purl.uniprot.org/citations/27617429 | http://purl.uniprot.org/core/author | "Olivera B.M."xsd:string |
| http://purl.uniprot.org/citations/27617429 | http://purl.uniprot.org/core/author | "Rivier J.E."xsd:string |
| http://purl.uniprot.org/citations/27617429 | http://purl.uniprot.org/core/author | "Rivier J.E."xsd:string |
| http://purl.uniprot.org/citations/27617429 | http://purl.uniprot.org/core/author | "Gajewiak J."xsd:string |
| http://purl.uniprot.org/citations/27617429 | http://purl.uniprot.org/core/author | "Gajewiak J."xsd:string |
| http://purl.uniprot.org/citations/27617429 | http://purl.uniprot.org/core/author | "Safavi-Hemami H."xsd:string |
| http://purl.uniprot.org/citations/27617429 | http://purl.uniprot.org/core/author | "Safavi-Hemami H."xsd:string |