| http://purl.uniprot.org/citations/27646874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27646874 | http://www.w3.org/2000/01/rdf-schema#comment | "Matrix metalloproteinases (MMPs) are zinc-containing endopeptidases that play roles in cell proliferation, migration, differentiation, angiogenesis, and apoptosis. The expression of MMP gene is tightly regulated and shows cell- and tissue-specific expression patterns. Despite their differential expression, MMP genes have AP-1 (activator protein-1) binding elements within their promoters. Interestingly, c-JUN phosphorylation by cytokine signaling decreased its interaction with NCoR, but increased its interaction with p300, resulting in activation of MMP gene transcription. Here, we found that Zbtb7c (Kr-pok) is a critical component of a transcriptional repressor complex containing c-Jun and NCoR. c-Jun, bound at AP-1, interacts with Zbtb7c, which in turn recruits an NCoR/Hdac3 complex to repress several Mmp (-8, -10, -13, and -16) genes. The molecular interaction between c-Jun and Zbtb7c also prevents phosphorylation of c-Jun by p-Jnk, However, Zbtb7c phosphorylation by p-Jnk (induced by TNFα), and its (Zbtb7c) subsequent degradation by the ubiquitin-mediated proteasomal pathway, leads to c-Jun phosphorylation by p-Jnk. Promoter-bound p-c-Jun then recruits the coactivator p300 to upregulate Mmp gene. Overall, these findings show that Zbtb7c is a key molecule that recruits an NCoR/Hdac3 complex to inhibit phosphorylation of c-Jun, and thereby repress Mmp gene expression."xsd:string |
| http://purl.uniprot.org/citations/27646874 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbagrm.2016.09.004"xsd:string |
| http://purl.uniprot.org/citations/27646874 | http://purl.uniprot.org/core/author | "Kim K."xsd:string |
| http://purl.uniprot.org/citations/27646874 | http://purl.uniprot.org/core/author | "Kim K.S."xsd:string |
| http://purl.uniprot.org/citations/27646874 | http://purl.uniprot.org/core/author | "Yoon J.H."xsd:string |
| http://purl.uniprot.org/citations/27646874 | http://purl.uniprot.org/core/author | "Kim M.K."xsd:string |
| http://purl.uniprot.org/citations/27646874 | http://purl.uniprot.org/core/author | "Hur M.W."xsd:string |
| http://purl.uniprot.org/citations/27646874 | http://purl.uniprot.org/core/author | "Choi W.I."xsd:string |
| http://purl.uniprot.org/citations/27646874 | http://purl.uniprot.org/core/author | "Jeon B.N."xsd:string |
| http://purl.uniprot.org/citations/27646874 | http://purl.uniprot.org/core/author | "Koh D.I."xsd:string |
| http://purl.uniprot.org/citations/27646874 | http://purl.uniprot.org/core/author | "Hur B."xsd:string |
| http://purl.uniprot.org/citations/27646874 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27646874 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/27646874 | http://purl.uniprot.org/core/pages | "1429-1439"xsd:string |
| http://purl.uniprot.org/citations/27646874 | http://purl.uniprot.org/core/title | "Zbtb7c is a molecular 'off' and 'on' switch of Mmp gene transcription."xsd:string |
| http://purl.uniprot.org/citations/27646874 | http://purl.uniprot.org/core/volume | "1859"xsd:string |
| http://purl.uniprot.org/citations/27646874 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27646874 |
| http://purl.uniprot.org/citations/27646874 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27646874 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUE3-mappedCitation-27646874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27646874 |
| http://purl.uniprot.org/uniprot/#_E9Q9Y2-mappedCitation-27646874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27646874 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUR3-mappedCitation-27646874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27646874 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUT9-mappedCitation-27646874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27646874 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YV90-mappedCitation-27646874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27646874 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YVC9-mappedCitation-27646874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27646874 |