| http://purl.uniprot.org/citations/27775713 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27775713 | http://www.w3.org/2000/01/rdf-schema#comment | "Complement is a key component of the innate immune system, recognizing pathogens and promoting their elimination. Complement component 3 (C3) is the central component of the system. Activation of C3 can be initiated by three distinct routes-the classical, the lectin and the alternative pathways-with the alternative pathway also acting as an amplification loop for the other two pathways. The protease factor D (FD) is essential for this amplification process, which, when dysregulated, predisposes individuals to diverse disorders including age-related macular degeneration and paroxysmal nocturnal hemoglobinuria (PNH). Here we describe the identification of potent and selective small-molecule inhibitors of FD. These inhibitors efficiently block alternative pathway (AP) activation and prevent both C3 deposition onto, and lysis of, PNH erythrocytes. Their oral administration inhibited lipopolysaccharide-induced AP activation in FD-humanized mice. These data demonstrate the feasibility of inhibiting the AP with small-molecule antagonists and support the development of FD inhibitors for the treatment of complement-mediated diseases."xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.org/dc/terms/identifier | "doi:10.1038/nchembio.2208"xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.uniprot.org/core/author | "Delgado O."xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.uniprot.org/core/author | "Barbieri S."xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.uniprot.org/core/author | "Harrison R."xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.uniprot.org/core/author | "Anderson K."xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.uniprot.org/core/author | "Eder J."xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.uniprot.org/core/author | "Kinzel B."xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.uniprot.org/core/author | "Kolb F.A."xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.uniprot.org/core/author | "Wagner J."xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.uniprot.org/core/author | "Erbel P."xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.uniprot.org/core/author | "Hommel U."xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.uniprot.org/core/author | "Durand C."xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.uniprot.org/core/author | "Gerhartz B."xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.uniprot.org/core/author | "Maibaum J."xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.uniprot.org/core/author | "Ostermann N."xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.uniprot.org/core/author | "Mac Sweeney A."xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.uniprot.org/core/author | "Hughes N."xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.uniprot.org/core/author | "Schubart A."xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.uniprot.org/core/author | "Liao S.M."xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.uniprot.org/core/author | "Jaffee B."xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.uniprot.org/core/author | "Cumin F."xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.uniprot.org/core/author | "Risitano A.M."xsd:string |
| http://purl.uniprot.org/citations/27775713 | http://purl.uniprot.org/core/author | "Vulpetti A."xsd:string |