| http://purl.uniprot.org/citations/27893700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27893700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27893700 | http://www.w3.org/2000/01/rdf-schema#comment | "The cellular sources of interleukin 6 (IL-6) that are relevant for differentiation of the TH17 subset of helper T cells remain unclear. Here we used a novel strategy for the conditional deletion of distinct IL-6-producing cell types to show that dendritic cells (DCs) positive for the signaling regulator Sirpα were essential for the generation of pathogenic TH17 cells. Using their IL-6 receptor α-chain (IL-6Rα), Sirpα+ DCs trans-presented IL-6 to T cells during the process of cognate interaction. While ambient IL-6 was sufficient to suppress the induction of expression of the transcription factor Foxp3 in T cells, trans-presentation of IL-6 by DC-bound IL-6Rα (called 'IL-6 cluster signaling' here) was needed to prevent premature induction of interferon-γ (IFN-γ) expression in T cells and to generate pathogenic TH17 cells in vivo. Our findings should guide therapeutic approaches for the treatment of TH17-cell-mediated autoimmune diseases."xsd:string |
| http://purl.uniprot.org/citations/27893700 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.3632"xsd:string |
| http://purl.uniprot.org/citations/27893700 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.3632"xsd:string |
| http://purl.uniprot.org/citations/27893700 | http://purl.uniprot.org/core/author | "Blum H."xsd:string |
| http://purl.uniprot.org/citations/27893700 | http://purl.uniprot.org/core/author | "Blum H."xsd:string |
| http://purl.uniprot.org/citations/27893700 | http://purl.uniprot.org/core/author | "Hidalgo J."xsd:string |
| http://purl.uniprot.org/citations/27893700 | http://purl.uniprot.org/core/author | "Hidalgo J."xsd:string |
| http://purl.uniprot.org/citations/27893700 | http://purl.uniprot.org/core/author | "Garbers C."xsd:string |
| http://purl.uniprot.org/citations/27893700 | http://purl.uniprot.org/core/author | "Garbers C."xsd:string |
| http://purl.uniprot.org/citations/27893700 | http://purl.uniprot.org/core/author | "Misgeld T."xsd:string |
| http://purl.uniprot.org/citations/27893700 | http://purl.uniprot.org/core/author | "Misgeld T."xsd:string |
| http://purl.uniprot.org/citations/27893700 | http://purl.uniprot.org/core/author | "Krebs S."xsd:string |
| http://purl.uniprot.org/citations/27893700 | http://purl.uniprot.org/core/author | "Krebs S."xsd:string |
| http://purl.uniprot.org/citations/27893700 | http://purl.uniprot.org/core/author | "Rose-John S."xsd:string |
| http://purl.uniprot.org/citations/27893700 | http://purl.uniprot.org/core/author | "Rose-John S."xsd:string |
| http://purl.uniprot.org/citations/27893700 | http://purl.uniprot.org/core/author | "Moeller-Hackbarth K."xsd:string |
| http://purl.uniprot.org/citations/27893700 | http://purl.uniprot.org/core/author | "Moeller-Hackbarth K."xsd:string |
| http://purl.uniprot.org/citations/27893700 | http://purl.uniprot.org/core/author | "Waisman A."xsd:string |
| http://purl.uniprot.org/citations/27893700 | http://purl.uniprot.org/core/author | "Waisman A."xsd:string |
| http://purl.uniprot.org/citations/27893700 | http://purl.uniprot.org/core/author | "Schmidt-Supprian M."xsd:string |
| http://purl.uniprot.org/citations/27893700 | http://purl.uniprot.org/core/author | "Schmidt-Supprian M."xsd:string |
| http://purl.uniprot.org/citations/27893700 | http://purl.uniprot.org/core/author | "Hemmer B."xsd:string |
| http://purl.uniprot.org/citations/27893700 | http://purl.uniprot.org/core/author | "Hemmer B."xsd:string |