| http://purl.uniprot.org/citations/27934701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27934701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27934701 | http://www.w3.org/2000/01/rdf-schema#comment | "Ribosomes stall when they encounter the end of messenger RNA (mRNA) without an in-frame stop codon. In bacteria, these "nonstop" complexes can be rescued by alternative ribosome-rescue factor A (ArfA). We used electron cryomicroscopy to determine structures of ArfA bound to the ribosome with 3'-truncated mRNA, at resolutions ranging from 3.0 to 3.4 angstroms. ArfA binds within the ribosomal mRNA channel and substitutes for the absent stop codon in the A site by specifically recruiting release factor 2 (RF2), initially in a compact preaccommodated state. A similar conformation of RF2 may occur on stop codons, suggesting a general mechanism for release-factor-mediated translational termination in which a conformational switch leads to peptide release only when the appropriate signal is present in the A site."xsd:string |
| http://purl.uniprot.org/citations/27934701 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aai9127"xsd:string |
| http://purl.uniprot.org/citations/27934701 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aai9127"xsd:string |
| http://purl.uniprot.org/citations/27934701 | http://purl.uniprot.org/core/author | "Brown A."xsd:string |
| http://purl.uniprot.org/citations/27934701 | http://purl.uniprot.org/core/author | "Brown A."xsd:string |
| http://purl.uniprot.org/citations/27934701 | http://purl.uniprot.org/core/author | "Ramakrishnan V."xsd:string |
| http://purl.uniprot.org/citations/27934701 | http://purl.uniprot.org/core/author | "Ramakrishnan V."xsd:string |
| http://purl.uniprot.org/citations/27934701 | http://purl.uniprot.org/core/author | "Gordiyenko Y."xsd:string |
| http://purl.uniprot.org/citations/27934701 | http://purl.uniprot.org/core/author | "Gordiyenko Y."xsd:string |
| http://purl.uniprot.org/citations/27934701 | http://purl.uniprot.org/core/author | "James N.R."xsd:string |
| http://purl.uniprot.org/citations/27934701 | http://purl.uniprot.org/core/author | "James N.R."xsd:string |
| http://purl.uniprot.org/citations/27934701 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27934701 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27934701 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/27934701 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/27934701 | http://purl.uniprot.org/core/pages | "1437-1440"xsd:string |
| http://purl.uniprot.org/citations/27934701 | http://purl.uniprot.org/core/pages | "1437-1440"xsd:string |
| http://purl.uniprot.org/citations/27934701 | http://purl.uniprot.org/core/title | "Translational termination without a stop codon."xsd:string |
| http://purl.uniprot.org/citations/27934701 | http://purl.uniprot.org/core/title | "Translational termination without a stop codon."xsd:string |
| http://purl.uniprot.org/citations/27934701 | http://purl.uniprot.org/core/volume | "354"xsd:string |
| http://purl.uniprot.org/citations/27934701 | http://purl.uniprot.org/core/volume | "354"xsd:string |
| http://purl.uniprot.org/citations/27934701 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27934701 |
| http://purl.uniprot.org/citations/27934701 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27934701 |