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http://purl.uniprot.org/citations/28183528http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/28183528http://www.w3.org/2000/01/rdf-schema#comment"

Introduction

Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood.

Methods

We conducted a transethnic genome-wide association study (GWAS) for late-onset AD in Stage 1 sample including whites of European Ancestry, African-Americans, Japanese, and Israeli-Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset.

Results

Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P < 5 × 10-8) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1 and for the interaction of the (apolipoprotein E) APOE ε4 allele with NFIC SNP. We also obtained GWS evidence (P < 2.7 × 10-6) for gene-based association in the total sample with a novel locus, TPBG (P = 1.8 × 10-6).

Discussion

Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci."xsd:string
http://purl.uniprot.org/citations/28183528http://purl.org/dc/terms/identifier"doi:10.1016/j.jalz.2016.12.012"xsd:string
http://purl.uniprot.org/citations/28183528http://purl.uniprot.org/core/author"Buxbaum J.D."xsd:string
http://purl.uniprot.org/citations/28183528http://purl.uniprot.org/core/author"Cao C."xsd:string
http://purl.uniprot.org/citations/28183528http://purl.uniprot.org/core/author"Li G."xsd:string
http://purl.uniprot.org/citations/28183528http://purl.uniprot.org/core/author"Kim R."xsd:string
http://purl.uniprot.org/citations/28183528http://purl.uniprot.org/core/author"Kuwano R."xsd:string
http://purl.uniprot.org/citations/28183528http://purl.uniprot.org/core/author"Masliah E."xsd:string
http://purl.uniprot.org/citations/28183528http://purl.uniprot.org/core/author"Sano M."xsd:string
http://purl.uniprot.org/citations/28183528http://purl.uniprot.org/core/author"Smith A.G."xsd:string
http://purl.uniprot.org/citations/28183528http://purl.uniprot.org/core/author"Zhang X."xsd:string
http://purl.uniprot.org/citations/28183528http://purl.uniprot.org/core/author"Yu L."xsd:string
http://purl.uniprot.org/citations/28183528http://purl.uniprot.org/core/author"Williamson J."xsd:string
http://purl.uniprot.org/citations/28183528http://purl.uniprot.org/core/author"Mukherjee S."xsd:string
http://purl.uniprot.org/citations/28183528http://purl.uniprot.org/core/author"Ferris S."xsd:string
http://purl.uniprot.org/citations/28183528http://purl.uniprot.org/core/author"Chung J."xsd:string
http://purl.uniprot.org/citations/28183528http://purl.uniprot.org/core/author"Boeve B.F."xsd:string
http://purl.uniprot.org/citations/28183528http://purl.uniprot.org/core/author"Cairns N.J."xsd:string
http://purl.uniprot.org/citations/28183528http://purl.uniprot.org/core/author"Dickson D.W."xsd:string
http://purl.uniprot.org/citations/28183528http://purl.uniprot.org/core/author"Ghetti B."xsd:string
http://purl.uniprot.org/citations/28183528http://purl.uniprot.org/core/author"Petersen R.C."xsd:string
http://purl.uniprot.org/citations/28183528http://purl.uniprot.org/core/author"Spina S."xsd:string
http://purl.uniprot.org/citations/28183528http://purl.uniprot.org/core/author"Barmada M.M."xsd:string
http://purl.uniprot.org/citations/28183528http://purl.uniprot.org/core/author"Atwood C.S."xsd:string
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