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| http://purl.uniprot.org/citations/28188673 | http://www.w3.org/2000/01/rdf-schema#comment | "Inhibition of immune checkpoint molecules, PD-1 and CTLA4, has been shown to be a promising cancer treatment. PD-1 and CTLA4 inhibit TCR and co-stimulatory signals. The third T cell activation signal represents the signals from the cytokine receptors. The cytokine interferon-γ (IFNγ) plays an important role in anti-tumor immunity by activating cytotoxic T cells (CTLs). Most cytokines use the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway, and the suppressors of cytokine signaling (SOCS) family of proteins are major negative regulators of the JAK/STAT pathway. Among SOCS proteins, CIS, SOCS1, and SOCS3 proteins can be considered the third immunocheckpoint molecules since they regulate cytokine signals that control the polarization of CD4+ T cells and the maturation of CD8+ T cells. This review summarizes recent progress on CIS, SOCS1, and SOCS3 in terms of their anti-tumor immunity and potential applications."xsd:string |
| http://purl.uniprot.org/citations/28188673 | http://purl.org/dc/terms/identifier | "doi:10.1111/cas.13194"xsd:string |
| http://purl.uniprot.org/citations/28188673 | http://purl.uniprot.org/core/author | "Kanamori M."xsd:string |
| http://purl.uniprot.org/citations/28188673 | http://purl.uniprot.org/core/author | "Yoshimura A."xsd:string |
| http://purl.uniprot.org/citations/28188673 | http://purl.uniprot.org/core/author | "Chikuma S."xsd:string |
| http://purl.uniprot.org/citations/28188673 | http://purl.uniprot.org/core/author | "Mise-Omata S."xsd:string |
| http://purl.uniprot.org/citations/28188673 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28188673 | http://purl.uniprot.org/core/name | "Cancer Sci"xsd:string |
| http://purl.uniprot.org/citations/28188673 | http://purl.uniprot.org/core/pages | "574-580"xsd:string |
| http://purl.uniprot.org/citations/28188673 | http://purl.uniprot.org/core/title | "Suppressors of cytokine signaling: Potential immune checkpoint molecules for cancer immunotherapy."xsd:string |
| http://purl.uniprot.org/citations/28188673 | http://purl.uniprot.org/core/volume | "108"xsd:string |
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