| http://purl.uniprot.org/citations/28232469 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28232469 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite the identification of several oncogenic driver mutations leading to constitutive JAK-STAT activation, the cellular and molecular biology of myeloproliferative neoplasms (MPN) remains incompletely understood. Recent discoveries have identified underlying disease-modifying molecular aberrations contributing to disease initiation and progression. Here, we report that deletion of Nol3 (Nucleolar protein 3) in mice leads to an MPN resembling primary myelofibrosis (PMF). Nol3-/- MPN mice harbor an expanded Thy1+LSK stem cell population exhibiting increased cell cycling and a myelomonocytic differentiation bias. Molecularly, this phenotype is mediated by Nol3-/--induced JAK-STAT activation and downstream activation of cyclin-dependent kinase 6 (Cdk6) and MycNol3-/- MPN Thy1+LSK cells share significant molecular similarities with primary CD34+ cells from PMF patients. NOL3 levels are decreased in CD34+ cells from PMF patients, and the NOL3 locus is deleted in a subset of patients with myeloid malignancies. Our results reveal a novel genetic PMF-like mouse model and identify a tumor suppressor role for NOL3 in the pathogenesis of myeloid malignancies."xsd:string |
| http://purl.uniprot.org/citations/28232469 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20162089"xsd:string |
| http://purl.uniprot.org/citations/28232469 | http://purl.uniprot.org/core/author | "Mitchell K."xsd:string |
| http://purl.uniprot.org/citations/28232469 | http://purl.uniprot.org/core/author | "McMahon C."xsd:string |
| http://purl.uniprot.org/citations/28232469 | http://purl.uniprot.org/core/author | "Hirsch C."xsd:string |
| http://purl.uniprot.org/citations/28232469 | http://purl.uniprot.org/core/author | "Kitsis R.N."xsd:string |
| http://purl.uniprot.org/citations/28232469 | http://purl.uniprot.org/core/author | "Walter D."xsd:string |
| http://purl.uniprot.org/citations/28232469 | http://purl.uniprot.org/core/author | "Maciejewski J.P."xsd:string |
| http://purl.uniprot.org/citations/28232469 | http://purl.uniprot.org/core/author | "Makishima H."xsd:string |
| http://purl.uniprot.org/citations/28232469 | http://purl.uniprot.org/core/author | "Gritsman K."xsd:string |
| http://purl.uniprot.org/citations/28232469 | http://purl.uniprot.org/core/author | "Bartholdy B."xsd:string |
| http://purl.uniprot.org/citations/28232469 | http://purl.uniprot.org/core/author | "Stanley R.F."xsd:string |
| http://purl.uniprot.org/citations/28232469 | http://purl.uniprot.org/core/author | "Steidl U."xsd:string |
| http://purl.uniprot.org/citations/28232469 | http://purl.uniprot.org/core/author | "Todorova T.I."xsd:string |
| http://purl.uniprot.org/citations/28232469 | http://purl.uniprot.org/core/author | "Will B."xsd:string |
| http://purl.uniprot.org/citations/28232469 | http://purl.uniprot.org/core/author | "McKimpson W.M."xsd:string |
| http://purl.uniprot.org/citations/28232469 | http://purl.uniprot.org/core/author | "Piszczatowski R.T."xsd:string |
| http://purl.uniprot.org/citations/28232469 | http://purl.uniprot.org/core/author | "Narayanagari S."xsd:string |
| http://purl.uniprot.org/citations/28232469 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28232469 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/28232469 | http://purl.uniprot.org/core/pages | "753-771"xsd:string |
| http://purl.uniprot.org/citations/28232469 | http://purl.uniprot.org/core/title | "A myeloid tumor suppressor role for NOL3."xsd:string |
| http://purl.uniprot.org/citations/28232469 | http://purl.uniprot.org/core/volume | "214"xsd:string |
| http://purl.uniprot.org/citations/28232469 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28232469 |