| http://purl.uniprot.org/citations/2828370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2828370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2828370 | http://www.w3.org/2000/01/rdf-schema#comment | "There is evidence that the gene for the B isozyme of creatine kinase is regulated during cell differentiation, is under hormonal control, and is activated in a small cell lung carcinoma. In order to investigate further the mechanisms of these processes, the human gene was isolated and the structure of the promoter region was determined. A human DNA fragment of 8 kilobase pairs was shown to encompass the entire coding region and 850 base pairs (bp) of the 5'-flanking sequence. This fragment was transfected into three cell lines and shown to express functional enzyme. The 5'-end of the gene is split by a 230-bp intron that is located 12 bp upstream of the initiator ATG codon. Transcription initiation occurs at a site that is approximately 69 bp upstream of the 5'-end of this intron. The DNA sequence in the region upstream of the 5'-end of the mRNA is suggestive of two superimposed promoters that contain additional sequence elements that are known to regulate expression of other eukaryote genes. The 5'-region also has a remarkable homology to the overlapping promoters of the adenovirus EIIaE gene. These elements collectively form the basis for initial investigations of how this gene is controlled."xsd:string |
| http://purl.uniprot.org/citations/2828370 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)69226-9"xsd:string |
| http://purl.uniprot.org/citations/2828370 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)69226-9"xsd:string |
| http://purl.uniprot.org/citations/2828370 | http://purl.uniprot.org/core/author | "Schimmel P."xsd:string |
| http://purl.uniprot.org/citations/2828370 | http://purl.uniprot.org/core/author | "Schimmel P."xsd:string |
| http://purl.uniprot.org/citations/2828370 | http://purl.uniprot.org/core/author | "Kingston R."xsd:string |
| http://purl.uniprot.org/citations/2828370 | http://purl.uniprot.org/core/author | "Kingston R."xsd:string |
| http://purl.uniprot.org/citations/2828370 | http://purl.uniprot.org/core/author | "Daouk G.H."xsd:string |
| http://purl.uniprot.org/citations/2828370 | http://purl.uniprot.org/core/author | "Daouk G.H."xsd:string |
| http://purl.uniprot.org/citations/2828370 | http://purl.uniprot.org/core/author | "Putney S."xsd:string |
| http://purl.uniprot.org/citations/2828370 | http://purl.uniprot.org/core/author | "Putney S."xsd:string |
| http://purl.uniprot.org/citations/2828370 | http://purl.uniprot.org/core/author | "Kaddurah-Daouk R."xsd:string |
| http://purl.uniprot.org/citations/2828370 | http://purl.uniprot.org/core/author | "Kaddurah-Daouk R."xsd:string |
| http://purl.uniprot.org/citations/2828370 | http://purl.uniprot.org/core/date | "1988"xsd:gYear |
| http://purl.uniprot.org/citations/2828370 | http://purl.uniprot.org/core/date | "1988"xsd:gYear |
| http://purl.uniprot.org/citations/2828370 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/2828370 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/2828370 | http://purl.uniprot.org/core/pages | "2442-2446"xsd:string |
| http://purl.uniprot.org/citations/2828370 | http://purl.uniprot.org/core/pages | "2442-2446"xsd:string |
| http://purl.uniprot.org/citations/2828370 | http://purl.uniprot.org/core/title | "Isolation of a functional human gene for brain creatine kinase."xsd:string |
| http://purl.uniprot.org/citations/2828370 | http://purl.uniprot.org/core/title | "Isolation of a functional human gene for brain creatine kinase."xsd:string |
| http://purl.uniprot.org/citations/2828370 | http://purl.uniprot.org/core/volume | "263"xsd:string |
| http://purl.uniprot.org/citations/2828370 | http://purl.uniprot.org/core/volume | "263"xsd:string |