| http://purl.uniprot.org/citations/28351934 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28351934 | http://www.w3.org/2000/01/rdf-schema#comment | "The clinical significance of MYC and BCL2 genetic alterations in diffuse large B-cell lymphoma (DLBCL), apart from translocations, has not been comprehensively investigated using high-resolution genetic assays. In this study, we profiled MYC and BCL2 genetic alterations using next-generation sequencing and high-resolution SNP array in 347 de novo DLBCL cases treated with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) at the British Columbia Cancer Agency. Cell-of-origin (COO) subtype was determined by Lymph2Cx digital gene expression profiling. We showed that the incidence of MYC/BCL2 genetic alterations and their clinical significance were largely dependent on COO subtypes. It is noteworthy that the presence of BCL2 gain/amplification is significantly associated with poor outcome in activated B-cell-like and BCL2 translocation with poor outcome in germinal center B-cell subtypes, respectively. Both have prognostic significance independent of MYC/BCL2 dual expression and the International Prognostic Index (IPI). Furthermore, the combination of BCL2 genetic alterations with IPI identifies markedly worse prognostic groups within individual COO subtypes. Thus, high-resolution genomic assays identify extremely poor prognostic groups within each COO subtype on the basis of BCL2 genetic status in this large, uniformly R-CHOP-treated population-based cohort of DLBCL. These results suggest COO subtype-specific biomarkers based on BCL2 genetic alterations can be used to risk-stratify patients with DLBCL treated with immunochemotherapy."xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2016-11-747022"xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.uniprot.org/core/author | "Marra M.A."xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.uniprot.org/core/author | "Morin R.D."xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.uniprot.org/core/author | "Lai D."xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.uniprot.org/core/author | "Boyle M."xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.uniprot.org/core/author | "Shah S.P."xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.uniprot.org/core/author | "Meissner B."xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.uniprot.org/core/author | "Gascoyne R.D."xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.uniprot.org/core/author | "Scott D.W."xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.uniprot.org/core/author | "Steidl C."xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.uniprot.org/core/author | "Connors J.M."xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.uniprot.org/core/author | "Ben-Neriah S."xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.uniprot.org/core/author | "Saberi S."xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.uniprot.org/core/author | "Savage K.J."xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.uniprot.org/core/author | "Farinha P."xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.uniprot.org/core/author | "Mottok A."xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.uniprot.org/core/author | "Ennishi D."xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.uniprot.org/core/author | "Hother C."xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.uniprot.org/core/author | "Bashashati A."xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.uniprot.org/core/author | "Sehn L.H."xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.uniprot.org/core/author | "Chan F.C."xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.uniprot.org/core/author | "Kridel R."xsd:string |
| http://purl.uniprot.org/citations/28351934 | http://purl.uniprot.org/core/author | "Shulha H.P."xsd:string |