| http://purl.uniprot.org/citations/2842060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2842060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2842060 | http://www.w3.org/2000/01/rdf-schema#comment | "Tyrosyl phosphorylation is implicated in the mechanism of insulin action. Mutation of the beta-subunit of the insulin receptor by substitution of tyrosyl residue 960 with phenylalanine had no effect on insulin-stimulated autophosphorylation or phosphotransferase activity of the purified receptor. However, unlike the normal receptor, this mutant was not biologically active in Chinese hamster ovary cells. Furthermore, insulin-stimulated tyrosyl phosphorylation of at least one endogenous substrate (pp185) was increased significantly in cells expressing the normal receptor but was barely detected in cells expressing the mutant. Therefore, beta-subunit autophosphorylation was not sufficient for the insulin response, and a region of the insulin receptor around Tyr-960 may facilitate phosphorylation of cellular substrates required for transmission of the insulin signal."xsd:string |
| http://purl.uniprot.org/citations/2842060 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(88)80008-4"xsd:string |
| http://purl.uniprot.org/citations/2842060 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(88)80008-4"xsd:string |
| http://purl.uniprot.org/citations/2842060 | http://purl.uniprot.org/core/author | "Kahn C.R."xsd:string |
| http://purl.uniprot.org/citations/2842060 | http://purl.uniprot.org/core/author | "Kahn C.R."xsd:string |
| http://purl.uniprot.org/citations/2842060 | http://purl.uniprot.org/core/author | "White M.F."xsd:string |
| http://purl.uniprot.org/citations/2842060 | http://purl.uniprot.org/core/author | "White M.F."xsd:string |
| http://purl.uniprot.org/citations/2842060 | http://purl.uniprot.org/core/author | "Ullrich A."xsd:string |
| http://purl.uniprot.org/citations/2842060 | http://purl.uniprot.org/core/author | "Ullrich A."xsd:string |
| http://purl.uniprot.org/citations/2842060 | http://purl.uniprot.org/core/author | "Backer J.M."xsd:string |
| http://purl.uniprot.org/citations/2842060 | http://purl.uniprot.org/core/author | "Backer J.M."xsd:string |
| http://purl.uniprot.org/citations/2842060 | http://purl.uniprot.org/core/author | "Dull T.J."xsd:string |
| http://purl.uniprot.org/citations/2842060 | http://purl.uniprot.org/core/author | "Dull T.J."xsd:string |
| http://purl.uniprot.org/citations/2842060 | http://purl.uniprot.org/core/author | "Livingston J.N."xsd:string |
| http://purl.uniprot.org/citations/2842060 | http://purl.uniprot.org/core/author | "Livingston J.N."xsd:string |
| http://purl.uniprot.org/citations/2842060 | http://purl.uniprot.org/core/author | "Lauris V."xsd:string |
| http://purl.uniprot.org/citations/2842060 | http://purl.uniprot.org/core/author | "Lauris V."xsd:string |
| http://purl.uniprot.org/citations/2842060 | http://purl.uniprot.org/core/date | "1988"xsd:gYear |
| http://purl.uniprot.org/citations/2842060 | http://purl.uniprot.org/core/date | "1988"xsd:gYear |
| http://purl.uniprot.org/citations/2842060 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/2842060 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/2842060 | http://purl.uniprot.org/core/pages | "641-649"xsd:string |
| http://purl.uniprot.org/citations/2842060 | http://purl.uniprot.org/core/pages | "641-649"xsd:string |