| http://purl.uniprot.org/citations/28463107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28463107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28463107 | http://www.w3.org/2000/01/rdf-schema#comment | "cAMP/PKA signalling is compartmentalised with tight spatial and temporal control of signal propagation underpinning specificity of response. The cAMP-degrading enzymes, phosphodiesterases (PDEs), localise to specific subcellular domains within which they control local cAMP levels and are key regulators of signal compartmentalisation. Several components of the cAMP/PKA cascade are located to different mitochondrial sub-compartments, suggesting the presence of multiple cAMP/PKA signalling domains within the organelle. The function and regulation of these domains remain largely unknown. Here, we describe a novel cAMP/PKA signalling domain localised at mitochondrial membranes and regulated by PDE2A2. Using pharmacological and genetic approaches combined with real-time FRET imaging and high resolution microscopy, we demonstrate that in rat cardiac myocytes and other cell types mitochondrial PDE2A2 regulates local cAMP levels and PKA-dependent phosphorylation of Drp1. We further demonstrate that inhibition of PDE2A, by enhancing the hormone-dependent cAMP response locally, affects mitochondria dynamics and protects from apoptotic cell death."xsd:string |
| http://purl.uniprot.org/citations/28463107 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.21374"xsd:string |
| http://purl.uniprot.org/citations/28463107 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.21374"xsd:string |
| http://purl.uniprot.org/citations/28463107 | http://purl.uniprot.org/core/author | "Gottlieb E."xsd:string |
| http://purl.uniprot.org/citations/28463107 | http://purl.uniprot.org/core/author | "Gottlieb E."xsd:string |
| http://purl.uniprot.org/citations/28463107 | http://purl.uniprot.org/core/author | "Castle J.C."xsd:string |
| http://purl.uniprot.org/citations/28463107 | http://purl.uniprot.org/core/author | "Castle J.C."xsd:string |
| http://purl.uniprot.org/citations/28463107 | http://purl.uniprot.org/core/author | "Bortolozzi M."xsd:string |
| http://purl.uniprot.org/citations/28463107 | http://purl.uniprot.org/core/author | "Bortolozzi M."xsd:string |
| http://purl.uniprot.org/citations/28463107 | http://purl.uniprot.org/core/author | "Micaroni M."xsd:string |
| http://purl.uniprot.org/citations/28463107 | http://purl.uniprot.org/core/author | "Micaroni M."xsd:string |
| http://purl.uniprot.org/citations/28463107 | http://purl.uniprot.org/core/author | "Weinberger M."xsd:string |
| http://purl.uniprot.org/citations/28463107 | http://purl.uniprot.org/core/author | "Weinberger M."xsd:string |
| http://purl.uniprot.org/citations/28463107 | http://purl.uniprot.org/core/author | "Baillie G."xsd:string |
| http://purl.uniprot.org/citations/28463107 | http://purl.uniprot.org/core/author | "Baillie G."xsd:string |
| http://purl.uniprot.org/citations/28463107 | http://purl.uniprot.org/core/author | "Livie C."xsd:string |
| http://purl.uniprot.org/citations/28463107 | http://purl.uniprot.org/core/author | "Livie C."xsd:string |
| http://purl.uniprot.org/citations/28463107 | http://purl.uniprot.org/core/author | "Lobo M.J."xsd:string |
| http://purl.uniprot.org/citations/28463107 | http://purl.uniprot.org/core/author | "Lobo M.J."xsd:string |
| http://purl.uniprot.org/citations/28463107 | http://purl.uniprot.org/core/author | "Maizels R."xsd:string |
| http://purl.uniprot.org/citations/28463107 | http://purl.uniprot.org/core/author | "Maizels R."xsd:string |
| http://purl.uniprot.org/citations/28463107 | http://purl.uniprot.org/core/author | "Monterisi S."xsd:string |
| http://purl.uniprot.org/citations/28463107 | http://purl.uniprot.org/core/author | "Monterisi S."xsd:string |