| http://purl.uniprot.org/citations/28564608 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28564608 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28564608 | http://www.w3.org/2000/01/rdf-schema#comment | "Endoglin (ENG)/CD105 is an essential endothelial cell co-receptor of the transforming growth factor β (TGF-β) superfamily, mutated in hereditary hemorrhagic telangiectasia type 1 (HHT1) and involved in tumor angiogenesis and preeclampsia. Here, we present crystal structures of the ectodomain of human ENG and its complex with the ligand bone morphogenetic protein 9 (BMP9). BMP9 interacts with a hydrophobic surface of the N-terminal orphan domain of ENG, which adopts a new duplicated fold generated by circular permutation. The interface involves residues mutated in HHT1 and overlaps with the epitope of tumor-suppressing anti-ENG monoclonal TRC105. The structure of the C-terminal zona pellucida module suggests how two copies of ENG embrace homodimeric BMP9, whose binding is compatible with ligand recognition by type I but not type II receptors. These findings shed light on the molecular basis of the BMP signaling cascade, with implications for future therapeutic interventions in this fundamental pathway."xsd:string |
| http://purl.uniprot.org/citations/28564608 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.05.011"xsd:string |
| http://purl.uniprot.org/citations/28564608 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.05.011"xsd:string |
| http://purl.uniprot.org/citations/28564608 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/28564608 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/28564608 | http://purl.uniprot.org/core/author | "Jovine L."xsd:string |
| http://purl.uniprot.org/citations/28564608 | http://purl.uniprot.org/core/author | "Jovine L."xsd:string |
| http://purl.uniprot.org/citations/28564608 | http://purl.uniprot.org/core/author | "de Sanctis D."xsd:string |
| http://purl.uniprot.org/citations/28564608 | http://purl.uniprot.org/core/author | "de Sanctis D."xsd:string |
| http://purl.uniprot.org/citations/28564608 | http://purl.uniprot.org/core/author | "Han L."xsd:string |
| http://purl.uniprot.org/citations/28564608 | http://purl.uniprot.org/core/author | "Han L."xsd:string |
| http://purl.uniprot.org/citations/28564608 | http://purl.uniprot.org/core/author | "Bokhove M."xsd:string |
| http://purl.uniprot.org/citations/28564608 | http://purl.uniprot.org/core/author | "Bokhove M."xsd:string |
| http://purl.uniprot.org/citations/28564608 | http://purl.uniprot.org/core/author | "Letarte M."xsd:string |
| http://purl.uniprot.org/citations/28564608 | http://purl.uniprot.org/core/author | "Letarte M."xsd:string |
| http://purl.uniprot.org/citations/28564608 | http://purl.uniprot.org/core/author | "Croci R."xsd:string |
| http://purl.uniprot.org/citations/28564608 | http://purl.uniprot.org/core/author | "Croci R."xsd:string |
| http://purl.uniprot.org/citations/28564608 | http://purl.uniprot.org/core/author | "Zamora-Caballero S."xsd:string |
| http://purl.uniprot.org/citations/28564608 | http://purl.uniprot.org/core/author | "Zamora-Caballero S."xsd:string |
| http://purl.uniprot.org/citations/28564608 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28564608 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28564608 | http://purl.uniprot.org/core/name | "Cell Rep."xsd:string |
| http://purl.uniprot.org/citations/28564608 | http://purl.uniprot.org/core/name | "Cell Rep."xsd:string |