| http://purl.uniprot.org/citations/28715417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28715417 | http://www.w3.org/2000/01/rdf-schema#comment | "Hox transcription factors specify distinct cell types along the anterior-posterior axis of metazoans by regulating target genes that modulate signaling pathways. A well-established example is the induction of Epidermal Growth Factor (EGF) signaling by an Abdominal-A (Abd-A) Hox complex during the specification of Drosophila hepatocyte-like cells (oenocytes). Previous studies revealed that Abd-A is non-cell autonomously required to promote oenocyte fate by directly activating a gene (rhomboid) that triggers EGF secretion from sensory organ precursor (SOP) cells. Neighboring cells that receive the EGF signal initiate a largely unknown pathway to promote oenocyte fate. Here, we show that Abd-A also plays a cell autonomous role in inducing oenocyte fate by activating the expression of the Pointed-P1 (PntP1) ETS transcription factor downstream of EGF signaling. Genetic studies demonstrate that both PntP1 and PntP2 are required for oenocyte specification. Moreover, we found that PntP1 contains a conserved enhancer (PntP1OE) that is activated in oenocyte precursor cells by EGF signaling via direct regulation by the Pnt transcription factors as well as a transcription factor complex consisting of Abd-A, Extradenticle, and Homothorax. Our findings demonstrate that the same Abd-A Hox complex required for sending the EGF signal from SOP cells, enhances the competency of receiving cells to select oenocyte cell fate by up-regulating PntP1. Since PntP1 is a downstream effector of EGF signaling, these findings provide insight into how a Hox factor can both trigger and potentiate the EGF signal to promote an essential cell fate along the body plan."xsd:string |
| http://purl.uniprot.org/citations/28715417 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1006910"xsd:string |
| http://purl.uniprot.org/citations/28715417 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/28715417 | http://purl.uniprot.org/core/author | "Li-Kroeger D."xsd:string |
| http://purl.uniprot.org/citations/28715417 | http://purl.uniprot.org/core/author | "Gebelein B."xsd:string |
| http://purl.uniprot.org/citations/28715417 | http://purl.uniprot.org/core/author | "Gutzwiller L."xsd:string |
| http://purl.uniprot.org/citations/28715417 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28715417 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/28715417 | http://purl.uniprot.org/core/pages | "e1006910"xsd:string |
| http://purl.uniprot.org/citations/28715417 | http://purl.uniprot.org/core/title | "A Hox complex activates and potentiates the Epidermal Growth Factor signaling pathway to specify Drosophila oenocytes."xsd:string |
| http://purl.uniprot.org/citations/28715417 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/28715417 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28715417 |
| http://purl.uniprot.org/citations/28715417 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28715417 |
| http://purl.uniprot.org/uniprot/P29555#attribution-1E5161FD69EBDB9CBB0F6E9D60FD200C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28715417 |
| http://purl.uniprot.org/uniprot/P29555#attribution-ABB359CA5BBDD727C0B47E3D9BA9CB20 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28715417 |
| http://purl.uniprot.org/uniprot/P29555#attribution-E4EA4557BE9A6D893E4E00D2AE66FC64 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28715417 |
| http://purl.uniprot.org/uniprot/P04412#attribution-E4EA4557BE9A6D893E4E00D2AE66FC64 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28715417 |
| http://purl.uniprot.org/uniprot/P40427#attribution-1E5161FD69EBDB9CBB0F6E9D60FD200C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28715417 |
| http://purl.uniprot.org/uniprot/P40427#attribution-ABB359CA5BBDD727C0B47E3D9BA9CB20 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28715417 |
| http://purl.uniprot.org/uniprot/O46339#attribution-1E5161FD69EBDB9CBB0F6E9D60FD200C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28715417 |
| http://purl.uniprot.org/uniprot/O46339#attribution-ABB359CA5BBDD727C0B47E3D9BA9CB20 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28715417 |
| http://purl.uniprot.org/uniprot/O46339#attribution-E4EA4557BE9A6D893E4E00D2AE66FC64 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28715417 |
| http://purl.uniprot.org/uniprot/P51023#attribution-E4EA4557BE9A6D893E4E00D2AE66FC64 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28715417 |
| http://purl.uniprot.org/uniprot/P20350#attribution-E4EA4557BE9A6D893E4E00D2AE66FC64 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28715417 |