| http://purl.uniprot.org/citations/28717225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28717225 | http://www.w3.org/2000/01/rdf-schema#comment | "Angiogenesis, new vessel formation from pre-existing vessels, is a highly conserved event through vertebrates. However, the system for tuning angiogenesis by species-intrinsic factors is totally unknown. miR-1224 is a member of mammal-specific mirtrons, which were identified as non-canonical microRNAs. We found that the expression of miR-1224 was upregulated in capillary-like tube-forming human umbilical vein endothelial cells on Matrigel. Enforced expression of miR-1224 stimulated tube formation, whereas repression of endogenous miR-1224 inhibited formation. Enforced expression of miR-1224 enhanced VEGF signaling and repressed NOTCH signaling. The adaptor protein of clathrin-dependent endocytosis, epsin2, which has been shown to be a suppressor of angiogenesis, was a direct target of miR-1224. Knockdown of EPN2 stimulated tube formation, while overexpression of EPN2 repressed miR-1224-mediated stimulation. Our findings indicate that miR-1224 is a mammal specific modulator of angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/28717225 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-05782-3"xsd:string |
| http://purl.uniprot.org/citations/28717225 | http://purl.uniprot.org/core/author | "Mizuguchi H."xsd:string |
| http://purl.uniprot.org/citations/28717225 | http://purl.uniprot.org/core/author | "Tachibana M."xsd:string |
| http://purl.uniprot.org/citations/28717225 | http://purl.uniprot.org/core/author | "Sakai E."xsd:string |
| http://purl.uniprot.org/citations/28717225 | http://purl.uniprot.org/core/author | "Miura Y."xsd:string |
| http://purl.uniprot.org/citations/28717225 | http://purl.uniprot.org/core/author | "Oka K."xsd:string |
| http://purl.uniprot.org/citations/28717225 | http://purl.uniprot.org/core/author | "Kawabata K."xsd:string |
| http://purl.uniprot.org/citations/28717225 | http://purl.uniprot.org/core/author | "Sakurai F."xsd:string |
| http://purl.uniprot.org/citations/28717225 | http://purl.uniprot.org/core/author | "Suzuki-Kouyama E."xsd:string |
| http://purl.uniprot.org/citations/28717225 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28717225 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/28717225 | http://purl.uniprot.org/core/pages | "5541"xsd:string |
| http://purl.uniprot.org/citations/28717225 | http://purl.uniprot.org/core/title | "A mammalian mirtron miR-1224 promotes tube-formation of human primary endothelial cells by targeting anti-angiogenic factor epsin2."xsd:string |
| http://purl.uniprot.org/citations/28717225 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/28717225 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28717225 |
| http://purl.uniprot.org/citations/28717225 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28717225 |
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| http://purl.uniprot.org/uniprot/O95208#attribution-07717F40D9817149A02EA33258A71799 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28717225 |
| http://purl.uniprot.org/uniprot/#_B7Z4W7-mappedCitation-28717225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28717225 |
| http://purl.uniprot.org/uniprot/#_B3KMB3-mappedCitation-28717225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28717225 |
| http://purl.uniprot.org/uniprot/#_B7ZKM5-mappedCitation-28717225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28717225 |
| http://purl.uniprot.org/uniprot/#_B7Z3A5-mappedCitation-28717225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28717225 |
| http://purl.uniprot.org/uniprot/#_O95208-mappedCitation-28717225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28717225 |