| http://purl.uniprot.org/citations/28826496 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28826496 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28826496 | http://www.w3.org/2000/01/rdf-schema#comment | "Altered Ca2+ handling is often present in diseased hearts undergoing structural remodeling and functional deterioration. However, whether Ca2+ directly regulates sarcomere structure has remained elusive. Using a zebrafish ncx1 mutant, we explored the impacts of impaired Ca2+ homeostasis on myofibril integrity. We found that the E3 ubiquitin ligase murf1 is upregulated in ncx1-deficient hearts. Intriguingly, knocking down murf1 activity or inhibiting proteasome activity preserved myofibril integrity, revealing a MuRF1-mediated proteasome degradation mechanism that is activated in response to abnormal Ca2+ homeostasis. Furthermore, we detected an accumulation of the murf1 regulator FoxO in the nuclei of ncx1-deficient cardiomyocytes. Overexpression of FoxO in wild type cardiomyocytes induced murf1 expression and caused myofibril disarray, whereas inhibiting Calcineurin activity attenuated FoxO-mediated murf1 expression and protected sarcomeres from degradation in ncx1-deficient hearts. Together, our findings reveal a novel mechanism by which Ca2+ overload disrupts myofibril integrity by activating a Calcineurin-FoxO-MuRF1-proteosome signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/28826496 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.27955"xsd:string |
| http://purl.uniprot.org/citations/28826496 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/28826496 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/28826496 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/28826496 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/28826496 | http://purl.uniprot.org/core/author | "Shimizu H."xsd:string |
| http://purl.uniprot.org/citations/28826496 | http://purl.uniprot.org/core/author | "Shimizu H."xsd:string |
| http://purl.uniprot.org/citations/28826496 | http://purl.uniprot.org/core/author | "Wang K."xsd:string |
| http://purl.uniprot.org/citations/28826496 | http://purl.uniprot.org/core/author | "Wang K."xsd:string |
| http://purl.uniprot.org/citations/28826496 | http://purl.uniprot.org/core/author | "Geisler R."xsd:string |
| http://purl.uniprot.org/citations/28826496 | http://purl.uniprot.org/core/author | "Geisler R."xsd:string |
| http://purl.uniprot.org/citations/28826496 | http://purl.uniprot.org/core/author | "Otto G."xsd:string |
| http://purl.uniprot.org/citations/28826496 | http://purl.uniprot.org/core/author | "Otto G."xsd:string |
| http://purl.uniprot.org/citations/28826496 | http://purl.uniprot.org/core/author | "Chen J.N."xsd:string |
| http://purl.uniprot.org/citations/28826496 | http://purl.uniprot.org/core/author | "Chen J.N."xsd:string |
| http://purl.uniprot.org/citations/28826496 | http://purl.uniprot.org/core/author | "Langenbacher A.D."xsd:string |
| http://purl.uniprot.org/citations/28826496 | http://purl.uniprot.org/core/author | "Langenbacher A.D."xsd:string |
| http://purl.uniprot.org/citations/28826496 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28826496 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28826496 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/28826496 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/28826496 | http://purl.uniprot.org/core/pages | "e27955"xsd:string |