| http://purl.uniprot.org/citations/29045903 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29045903 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29045903 | http://www.w3.org/2000/01/rdf-schema#comment | "Infection by helminth parasites is associated with amelioration of allergic reactivity, but mechanistic insights into this association are lacking. Products secreted by the mouse parasite Heligmosomoides polygyrus suppress type 2 (allergic) immune responses through interference in the interleukin-33 (IL-33) pathway. Here, we identified H. polygyrus Alarmin Release Inhibitor (HpARI), an IL-33-suppressive 26-kDa protein, containing three predicted complement control protein (CCP) modules. In vivo, recombinant HpARI abrogated IL-33, group 2 innate lymphoid cell (ILC2) and eosinophilic responses to Alternaria allergen administration, and diminished eosinophilic responses to Nippostrongylus brasiliensis, increasing parasite burden. HpARI bound directly to both mouse and human IL-33 (in the cytokine's activated state) and also to nuclear DNA via its N-terminal CCP module pair (CCP1/2), tethering active IL-33 within necrotic cells, preventing its release, and forestalling initiation of type 2 allergic responses. Thus, HpARI employs a novel molecular strategy to suppress type 2 immunity in both infection and allergy."xsd:string |
| http://purl.uniprot.org/citations/29045903 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2017.09.015"xsd:string |
| http://purl.uniprot.org/citations/29045903 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2017.09.015"xsd:string |
| http://purl.uniprot.org/citations/29045903 | http://purl.uniprot.org/core/author | "Henderson H."xsd:string |
| http://purl.uniprot.org/citations/29045903 | http://purl.uniprot.org/core/author | "Henderson H."xsd:string |
| http://purl.uniprot.org/citations/29045903 | http://purl.uniprot.org/core/author | "Ivens A.C."xsd:string |
| http://purl.uniprot.org/citations/29045903 | http://purl.uniprot.org/core/author | "Ivens A.C."xsd:string |
| http://purl.uniprot.org/citations/29045903 | http://purl.uniprot.org/core/author | "Soares D.C."xsd:string |
| http://purl.uniprot.org/citations/29045903 | http://purl.uniprot.org/core/author | "Soares D.C."xsd:string |
| http://purl.uniprot.org/citations/29045903 | http://purl.uniprot.org/core/author | "Scott I.C."xsd:string |
| http://purl.uniprot.org/citations/29045903 | http://purl.uniprot.org/core/author | "Scott I.C."xsd:string |
| http://purl.uniprot.org/citations/29045903 | http://purl.uniprot.org/core/author | "Gregory W.F."xsd:string |
| http://purl.uniprot.org/citations/29045903 | http://purl.uniprot.org/core/author | "Gregory W.F."xsd:string |
| http://purl.uniprot.org/citations/29045903 | http://purl.uniprot.org/core/author | "Vacca F."xsd:string |
| http://purl.uniprot.org/citations/29045903 | http://purl.uniprot.org/core/author | "Vacca F."xsd:string |
| http://purl.uniprot.org/citations/29045903 | http://purl.uniprot.org/core/author | "Smyth D.J."xsd:string |
| http://purl.uniprot.org/citations/29045903 | http://purl.uniprot.org/core/author | "Smyth D.J."xsd:string |
| http://purl.uniprot.org/citations/29045903 | http://purl.uniprot.org/core/author | "Maizels R.M."xsd:string |
| http://purl.uniprot.org/citations/29045903 | http://purl.uniprot.org/core/author | "Maizels R.M."xsd:string |
| http://purl.uniprot.org/citations/29045903 | http://purl.uniprot.org/core/author | "Astier A.L."xsd:string |
| http://purl.uniprot.org/citations/29045903 | http://purl.uniprot.org/core/author | "Astier A.L."xsd:string |
| http://purl.uniprot.org/citations/29045903 | http://purl.uniprot.org/core/author | "Cohen E.S."xsd:string |
| http://purl.uniprot.org/citations/29045903 | http://purl.uniprot.org/core/author | "Cohen E.S."xsd:string |