| http://purl.uniprot.org/citations/2906640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2906640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2906640 | http://www.w3.org/2000/01/rdf-schema#comment | "Expression of cyclin, a non-histone nuclear protein, during recombinant interleukin 2 (rIL2)-driven cell-cycle progression of cloned T lymphocytes has been assessed. We found that expression of cyclin protein, as detected by immunofluorescence, is tightly associated with proliferation, and not merely S-phase, of L2 cells stimulated with rIL2. Cyclin immunofluorescence was detected in all cell-cycle phases (G1/S/G2/M, as detected by flow cytometry) of proliferating L2 cells. Accumulation of cyclin mRNA levels was induced as early as 1 h after stimulation, was maximal at 25-49 h, and remained elevated throughout stimulation, as detected by Northern blot analysis. A cDNA-encoding murine cyclin was cloned from a cDNA library prepared from IL2-stimulated cloned T cells. The sequence of the 5' end of the murine cyclin cDNA was determined and found to be 88% and 82% similar to the sequences of cDNA clones encoding rat and human cyclin, respectively. The present studies demonstrate that cyclin protein and mRNA accumulation are highly regulated during IL2-induced proliferation of a cloned T cell. These data provide a framework for addressing the molecular mechanisms regulating cyclin gene expression during cellular proliferation."xsd:string |
| http://purl.uniprot.org/citations/2906640 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.240380306"xsd:string |
| http://purl.uniprot.org/citations/2906640 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.240380306"xsd:string |
| http://purl.uniprot.org/citations/2906640 | http://purl.uniprot.org/core/author | "Sullivan K."xsd:string |
| http://purl.uniprot.org/citations/2906640 | http://purl.uniprot.org/core/author | "Sullivan K."xsd:string |
| http://purl.uniprot.org/citations/2906640 | http://purl.uniprot.org/core/author | "Prystowsky M.B."xsd:string |
| http://purl.uniprot.org/citations/2906640 | http://purl.uniprot.org/core/author | "Prystowsky M.B."xsd:string |
| http://purl.uniprot.org/citations/2906640 | http://purl.uniprot.org/core/author | "Tan E.M."xsd:string |
| http://purl.uniprot.org/citations/2906640 | http://purl.uniprot.org/core/author | "Tan E.M."xsd:string |
| http://purl.uniprot.org/citations/2906640 | http://purl.uniprot.org/core/author | "Sabath D.E."xsd:string |
| http://purl.uniprot.org/citations/2906640 | http://purl.uniprot.org/core/author | "Sabath D.E."xsd:string |
| http://purl.uniprot.org/citations/2906640 | http://purl.uniprot.org/core/author | "Fischer A.H."xsd:string |
| http://purl.uniprot.org/citations/2906640 | http://purl.uniprot.org/core/author | "Fischer A.H."xsd:string |
| http://purl.uniprot.org/citations/2906640 | http://purl.uniprot.org/core/author | "Comber P.G."xsd:string |
| http://purl.uniprot.org/citations/2906640 | http://purl.uniprot.org/core/author | "Comber P.G."xsd:string |
| http://purl.uniprot.org/citations/2906640 | http://purl.uniprot.org/core/author | "Shipman P.M."xsd:string |
| http://purl.uniprot.org/citations/2906640 | http://purl.uniprot.org/core/author | "Shipman P.M."xsd:string |
| http://purl.uniprot.org/citations/2906640 | http://purl.uniprot.org/core/date | "1988"xsd:gYear |
| http://purl.uniprot.org/citations/2906640 | http://purl.uniprot.org/core/date | "1988"xsd:gYear |
| http://purl.uniprot.org/citations/2906640 | http://purl.uniprot.org/core/name | "J. Cell. Biochem."xsd:string |
| http://purl.uniprot.org/citations/2906640 | http://purl.uniprot.org/core/name | "J. Cell. Biochem."xsd:string |
| http://purl.uniprot.org/citations/2906640 | http://purl.uniprot.org/core/pages | "189-198"xsd:string |
| http://purl.uniprot.org/citations/2906640 | http://purl.uniprot.org/core/pages | "189-198"xsd:string |