| http://purl.uniprot.org/citations/29371969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29371969 | http://www.w3.org/2000/01/rdf-schema#comment | "Although large numbers of microRNAs (miRNAs) expressed in Alzheimer disease (AD) have been detected, their functions and mechanisms of regulation remain to be fully clarified. Beta-site Amyloid precursor protein Cleaving Enzyme 1 (BACE1) has been one of the prime therapeutic targets for AD. Here, we identified that miR-124 levels are gradually decreased in AD. In addition, we demonstrated that miR-124 suppresses BACE1 expression by directly targeting the 3'UTR of Bace1 mRNA in vitro. Inhibition of miR-124 significantly increased BACE1 levels in neuronal cells. In contrast, miR-124 overexpression significantly suppressed BACE1 expression in cells. And finally we determined that downregulation of miR-124 alleviated Aβ-induced viability inhibition and decreased apoptosis in SH-SY5Y cells. Our results demonstrated that miR-124 is a potent negative regulator of BACE1 in the cellular AD phenotype and might be involved in the pathogenesis of AD."xsd:string |
| http://purl.uniprot.org/citations/29371969 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.23119"xsd:string |
| http://purl.uniprot.org/citations/29371969 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/29371969 | http://purl.uniprot.org/core/author | "Yu L."xsd:string |
| http://purl.uniprot.org/citations/29371969 | http://purl.uniprot.org/core/author | "Wei C."xsd:string |
| http://purl.uniprot.org/citations/29371969 | http://purl.uniprot.org/core/author | "An F."xsd:string |
| http://purl.uniprot.org/citations/29371969 | http://purl.uniprot.org/core/author | "Bian M."xsd:string |
| http://purl.uniprot.org/citations/29371969 | http://purl.uniprot.org/core/author | "Gong G."xsd:string |
| http://purl.uniprot.org/citations/29371969 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29371969 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/29371969 | http://purl.uniprot.org/core/pages | "114065-114071"xsd:string |
| http://purl.uniprot.org/citations/29371969 | http://purl.uniprot.org/core/title | "MiR-124 acts as a target for Alzheimer's disease by regulating BACE1."xsd:string |
| http://purl.uniprot.org/citations/29371969 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/29371969 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29371969 |
| http://purl.uniprot.org/citations/29371969 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29371969 |
| http://purl.uniprot.org/uniprot/P56817#attribution-B18E1CC100012FC521AFC9EB6325E7DC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/29371969 |