| http://purl.uniprot.org/citations/29441883 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29441883 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies suggest that cytokines and microRNAs play a key role in the destruction of cartilage matrix in osteoarthritis (OA) tissues. In the current study, we focused on miR-204, which has never been explored in OA. We found that the level of miR-204 was markedly reduced in the OA cartilage tissues compared with that of normal control. Real time PCR analysis demonstrated that the level of miR-204 was markedly decreased after IL-1β treatment for 3, 6, 12 h in the normal chondrocytes and OA chondrocytes, respectively. Furthermore, overexpression of miR-204 markedly suppressed the protein levels of IL-1β, COX-2 and IL6 in human OA chondrocytes and chondrogenic SW1353 cells. Dual luciferase reporter assay demonstrated that miR-204 significantly suppressed the relative luciferase activity of pmirGLO-IL-1β-3'UTR, indicating that IL-1β was a target gene of miR-204. More importantly, treatment with IL-1β significantly enhanced the protein levels of IL-1β, COX-2 and IL6. However, overexpression of miR-204 could partially abolish such effects. In conclusion, our data demonstrate that reduced miR-204 expression enhances the destruction of the cartilage tissues among OA patients mainly through targeting IL-1β."xsd:string |
| http://purl.uniprot.org/citations/29441883 | http://purl.org/dc/terms/identifier | "doi:10.1691/ph.2017.7588"xsd:string |
| http://purl.uniprot.org/citations/29441883 | http://purl.uniprot.org/core/author | "Liu B."xsd:string |
| http://purl.uniprot.org/citations/29441883 | http://purl.uniprot.org/core/author | "Song X."xsd:string |
| http://purl.uniprot.org/citations/29441883 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/29441883 | http://purl.uniprot.org/core/author | "Yan Z."xsd:string |
| http://purl.uniprot.org/citations/29441883 | http://purl.uniprot.org/core/author | "Yin Y."xsd:string |
| http://purl.uniprot.org/citations/29441883 | http://purl.uniprot.org/core/author | "Zhu M."xsd:string |
| http://purl.uniprot.org/citations/29441883 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29441883 | http://purl.uniprot.org/core/name | "Pharmazie"xsd:string |
| http://purl.uniprot.org/citations/29441883 | http://purl.uniprot.org/core/pages | "587-592"xsd:string |
| http://purl.uniprot.org/citations/29441883 | http://purl.uniprot.org/core/title | "MiR-204 enhances the progression of osteoarthritis by suppressing the production of IL-1beta."xsd:string |
| http://purl.uniprot.org/citations/29441883 | http://purl.uniprot.org/core/volume | "72"xsd:string |
| http://purl.uniprot.org/citations/29441883 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29441883 |
| http://purl.uniprot.org/citations/29441883 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29441883 |
| http://purl.uniprot.org/uniprot/P01584#attribution-11C6473124B93596553B41F6223394DA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/29441883 |