| http://purl.uniprot.org/citations/29499138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29499138 | http://www.w3.org/2000/01/rdf-schema#comment | "Double-strand breaks (DSBs) are critical DNA lesions that robustly activate the elaborate DNA damage response (DDR) network. We identified a critical player in DDR fine-tuning: the E3/E4 ubiquitin ligase UBE4A. UBE4A's recruitment to sites of DNA damage is dependent on primary E3 ligases in the DDR and promotes enhancement and sustainment of K48- and K63-linked ubiquitin chains at these sites. This step is required for timely recruitment of the RAP80 and BRCA1 proteins and proper organization of RAP80- and BRCA1-associated protein complexes at DSB sites. This pathway is essential for optimal end resection at DSBs, and its abrogation leads to upregulation of the highly mutagenic alternative end-joining repair at the expense of error-free homologous recombination repair. Our data uncover a critical regulatory level in the DSB response and underscore the importance of fine-tuning the complex DDR network for accurate and balanced execution of DSB repair."xsd:string |
| http://purl.uniprot.org/citations/29499138 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2018.02.002"xsd:string |
| http://purl.uniprot.org/citations/29499138 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/29499138 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/29499138 | http://purl.uniprot.org/core/author | "Park Y."xsd:string |
| http://purl.uniprot.org/citations/29499138 | http://purl.uniprot.org/core/author | "Shiloh Y."xsd:string |
| http://purl.uniprot.org/citations/29499138 | http://purl.uniprot.org/core/author | "Voss T.C."xsd:string |
| http://purl.uniprot.org/citations/29499138 | http://purl.uniprot.org/core/author | "Yoon J.B."xsd:string |
| http://purl.uniprot.org/citations/29499138 | http://purl.uniprot.org/core/author | "Misteli T."xsd:string |
| http://purl.uniprot.org/citations/29499138 | http://purl.uniprot.org/core/author | "Huertas P."xsd:string |
| http://purl.uniprot.org/citations/29499138 | http://purl.uniprot.org/core/author | "Baranes-Bachar K."xsd:string |
| http://purl.uniprot.org/citations/29499138 | http://purl.uniprot.org/core/author | "Ziv Y."xsd:string |
| http://purl.uniprot.org/citations/29499138 | http://purl.uniprot.org/core/author | "Chung D."xsd:string |
| http://purl.uniprot.org/citations/29499138 | http://purl.uniprot.org/core/author | "Rothenberg E."xsd:string |
| http://purl.uniprot.org/citations/29499138 | http://purl.uniprot.org/core/author | "Dellaire G."xsd:string |
| http://purl.uniprot.org/citations/29499138 | http://purl.uniprot.org/core/author | "Ramadan K."xsd:string |
| http://purl.uniprot.org/citations/29499138 | http://purl.uniprot.org/core/author | "Oehler J."xsd:string |
| http://purl.uniprot.org/citations/29499138 | http://purl.uniprot.org/core/author | "Reid D.A."xsd:string |
| http://purl.uniprot.org/citations/29499138 | http://purl.uniprot.org/core/author | "Levy-Barda A."xsd:string |
| http://purl.uniprot.org/citations/29499138 | http://purl.uniprot.org/core/author | "Soria-Bretones I."xsd:string |
| http://purl.uniprot.org/citations/29499138 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29499138 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/29499138 | http://purl.uniprot.org/core/pages | "866-878.e7"xsd:string |
| http://purl.uniprot.org/citations/29499138 | http://purl.uniprot.org/core/title | "The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair."xsd:string |