| http://purl.uniprot.org/citations/29973724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29973724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29973724 | http://www.w3.org/2000/01/rdf-schema#comment | "Liquid-liquid phase separation has been shown to underlie the formation and disassembly of membraneless organelles in cells, but the cellular mechanisms that control this phenomenon are poorly understood. A prominent example of regulated and reversible segregation of liquid phases may occur during mitosis, when membraneless organelles disappear upon nuclear-envelope breakdown and reappear as mitosis is completed. Here we show that the dual-specificity kinase DYRK3 acts as a central dissolvase of several types of membraneless organelle during mitosis. DYRK3 kinase activity is essential to prevent the unmixing of the mitotic cytoplasm into aberrant liquid-like hybrid organelles and the over-nucleation of spindle bodies. Our work supports a mechanism in which the dilution of phase-separating proteins during nuclear-envelope breakdown and the DYRK3-dependent degree of their solubility combine to allow cells to dissolve and condense several membraneless organelles during mitosis."xsd:string |
| http://purl.uniprot.org/citations/29973724 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41586-018-0279-8"xsd:string |
| http://purl.uniprot.org/citations/29973724 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41586-018-0279-8"xsd:string |
| http://purl.uniprot.org/citations/29973724 | http://purl.uniprot.org/core/author | "Chen J.X."xsd:string |
| http://purl.uniprot.org/citations/29973724 | http://purl.uniprot.org/core/author | "Chen J.X."xsd:string |
| http://purl.uniprot.org/citations/29973724 | http://purl.uniprot.org/core/author | "Selbach M."xsd:string |
| http://purl.uniprot.org/citations/29973724 | http://purl.uniprot.org/core/author | "Selbach M."xsd:string |
| http://purl.uniprot.org/citations/29973724 | http://purl.uniprot.org/core/author | "Pelkmans L."xsd:string |
| http://purl.uniprot.org/citations/29973724 | http://purl.uniprot.org/core/author | "Pelkmans L."xsd:string |
| http://purl.uniprot.org/citations/29973724 | http://purl.uniprot.org/core/author | "Rai A.K."xsd:string |
| http://purl.uniprot.org/citations/29973724 | http://purl.uniprot.org/core/author | "Rai A.K."xsd:string |
| http://purl.uniprot.org/citations/29973724 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29973724 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29973724 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/29973724 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/29973724 | http://purl.uniprot.org/core/pages | "211-216"xsd:string |
| http://purl.uniprot.org/citations/29973724 | http://purl.uniprot.org/core/pages | "211-216"xsd:string |
| http://purl.uniprot.org/citations/29973724 | http://purl.uniprot.org/core/title | "Kinase-controlled phase transition of membraneless organelles in mitosis."xsd:string |
| http://purl.uniprot.org/citations/29973724 | http://purl.uniprot.org/core/title | "Kinase-controlled phase transition of membraneless organelles in mitosis."xsd:string |
| http://purl.uniprot.org/citations/29973724 | http://purl.uniprot.org/core/volume | "559"xsd:string |
| http://purl.uniprot.org/citations/29973724 | http://purl.uniprot.org/core/volume | "559"xsd:string |
| http://purl.uniprot.org/citations/29973724 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29973724 |
| http://purl.uniprot.org/citations/29973724 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29973724 |