| http://purl.uniprot.org/citations/30026228 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30026228 | http://www.w3.org/2000/01/rdf-schema#comment | "Inactivation of the von Hippel-Lindau (VHL) E3 ubiquitin ligase protein is a hallmark of clear cell renal cell carcinoma (ccRCC). Identifying how pathways affected by VHL loss contribute to ccRCC remains challenging. We used a genome-wide in vitro expression strategy to identify proteins that bind VHL when hydroxylated. Zinc fingers and homeoboxes 2 (ZHX2) was found as a VHL target, and its hydroxylation allowed VHL to regulate its protein stability. Tumor cells from ccRCC patients with VHL loss-of-function mutations usually had increased abundance and nuclear localization of ZHX2. Functionally, depletion of ZHX2 inhibited VHL-deficient ccRCC cell growth in vitro and in vivo. Mechanistically, integrated chromatin immunoprecipitation sequencing and microarray analysis showed that ZHX2 promoted nuclear factor κB activation. These studies reveal ZHX2 as a potential therapeutic target for ccRCC."xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aap8411"xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.uniprot.org/core/author | "Fan C."xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.uniprot.org/core/author | "Geng J."xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.uniprot.org/core/author | "Fan J."xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.uniprot.org/core/author | "Tan P."xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.uniprot.org/core/author | "Wu T."xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.uniprot.org/core/author | "Xie L."xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.uniprot.org/core/author | "Teh B.T."xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.uniprot.org/core/author | "Zheng X."xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.uniprot.org/core/author | "Hu L."xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.uniprot.org/core/author | "Simon J."xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.uniprot.org/core/author | "Saito R."xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.uniprot.org/core/author | "Parker J.S."xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.uniprot.org/core/author | "Yao X."xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.uniprot.org/core/author | "Lawrence C."xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.uniprot.org/core/author | "Kim W.Y."xsd:string |
| http://purl.uniprot.org/citations/30026228 | http://purl.uniprot.org/core/author | "Hong K."xsd:string |