| http://purl.uniprot.org/citations/30271964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30271964 | http://www.w3.org/2000/01/rdf-schema#comment | "Eosinophil degranulation is a determining factor in allergy-mediated airway pathology. Receptor-mediated degranulation in eosinophils requires vesicle-associated membrane protein 7 (VAMP-7), a principal component of the SNARE fusion machinery. The specific contribution of eosinophil degranulation to allergen-induced airway responses remains poorly understood. We generated mice with VAMP-7 gene deficiency exclusively in eosinophils (eoCRE/V7) from a cross using eosinophil-specific Cre recombinase-expressing mice crossed with VAMP-7 f/f mice. Eosinophils from eoCRE/V7 mice showed deficient degranulation responses in vitro, and responses continued to be decreased following ex vivo intratracheal adoptive transfer of eoCRE/V7 eosinophils into IL-5/hE2/EPX -/- mice. Consistent with diminished degranulation responses, reduced airway hyperresponsiveness was observed in ovalbumin-sensitized and challenged eoCRE/V7 mice following methacholine inhalation. Therefore, VAMP-7 mediates eosinophil degranulation both in vitro and ex vivo, and this event augments airway hyperresponsiveness."xsd:string |
| http://purl.uniprot.org/citations/30271964 | http://purl.org/dc/terms/identifier | "doi:10.1038/s42003-018-0081-z"xsd:string |
| http://purl.uniprot.org/citations/30271964 | http://purl.uniprot.org/core/author | "Lee J.J."xsd:string |
| http://purl.uniprot.org/citations/30271964 | http://purl.uniprot.org/core/author | "Luo H."xsd:string |
| http://purl.uniprot.org/citations/30271964 | http://purl.uniprot.org/core/author | "Kim J.D."xsd:string |
| http://purl.uniprot.org/citations/30271964 | http://purl.uniprot.org/core/author | "Moqbel R."xsd:string |
| http://purl.uniprot.org/citations/30271964 | http://purl.uniprot.org/core/author | "Lee N.A."xsd:string |
| http://purl.uniprot.org/citations/30271964 | http://purl.uniprot.org/core/author | "Puttagunta L."xsd:string |
| http://purl.uniprot.org/citations/30271964 | http://purl.uniprot.org/core/author | "Lacy P."xsd:string |
| http://purl.uniprot.org/citations/30271964 | http://purl.uniprot.org/core/author | "Ochkur S.I."xsd:string |
| http://purl.uniprot.org/citations/30271964 | http://purl.uniprot.org/core/author | "Jacobsen E.A."xsd:string |
| http://purl.uniprot.org/citations/30271964 | http://purl.uniprot.org/core/author | "Zellner K.R."xsd:string |
| http://purl.uniprot.org/citations/30271964 | http://purl.uniprot.org/core/author | "Condjella R.M."xsd:string |
| http://purl.uniprot.org/citations/30271964 | http://purl.uniprot.org/core/author | "Willetts L."xsd:string |
| http://purl.uniprot.org/citations/30271964 | http://purl.uniprot.org/core/author | "Felix L.C."xsd:string |
| http://purl.uniprot.org/citations/30271964 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30271964 | http://purl.uniprot.org/core/name | "Commun Biol"xsd:string |
| http://purl.uniprot.org/citations/30271964 | http://purl.uniprot.org/core/pages | "83"xsd:string |
| http://purl.uniprot.org/citations/30271964 | http://purl.uniprot.org/core/title | "Vesicle-associated membrane protein 7-mediated eosinophil degranulation promotes allergic airway inflammation in mice."xsd:string |
| http://purl.uniprot.org/citations/30271964 | http://purl.uniprot.org/core/volume | "1"xsd:string |
| http://purl.uniprot.org/citations/30271964 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30271964 |
| http://purl.uniprot.org/citations/30271964 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30271964 |
| http://purl.uniprot.org/uniprot/#_P49290-mappedCitation-30271964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30271964 |
| http://purl.uniprot.org/uniprot/#_P70280-mappedCitation-30271964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30271964 |