| http://purl.uniprot.org/citations/30883606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30883606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30883606 | http://www.w3.org/2000/01/rdf-schema#comment | "Phagocytosis is a complex process that eliminates microbes and is performed by specialised cells such as macrophages. Toll-like receptor 4 (TLR4) is expressed on the surface of macrophages and recognizes Gram-negative bacteria. Moreover, TLR4 has been suggested to play a role in the phagocytosis of Gram-negative bacteria, but the mechanisms remain unclear. Here we have used primary human macrophages and engineered THP-1 monocytes to show that the TLR4 sorting adapter, TRAM, is instrumental for phagocytosis of Escherichia coli as well as Staphylococcus aureus. We find that TRAM forms a complex with Rab11 family interacting protein 2 (FIP2) that is recruited to the phagocytic cups of E. coli. This promotes activation of the actin-regulatory GTPases Rac1 and Cdc42. Our results show that FIP2 guided TRAM recruitment orchestrates actin remodelling and IRF3 activation, two events that are both required for phagocytosis of Gram-negative bacteria."xsd:string |
| http://purl.uniprot.org/citations/30883606 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1007684"xsd:string |
| http://purl.uniprot.org/citations/30883606 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1007684"xsd:string |
| http://purl.uniprot.org/citations/30883606 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/30883606 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/30883606 | http://purl.uniprot.org/core/author | "Lentini G."xsd:string |
| http://purl.uniprot.org/citations/30883606 | http://purl.uniprot.org/core/author | "Lentini G."xsd:string |
| http://purl.uniprot.org/citations/30883606 | http://purl.uniprot.org/core/author | "Groevdal L.M."xsd:string |
| http://purl.uniprot.org/citations/30883606 | http://purl.uniprot.org/core/author | "Groevdal L.M."xsd:string |
| http://purl.uniprot.org/citations/30883606 | http://purl.uniprot.org/core/author | "Husebye H."xsd:string |
| http://purl.uniprot.org/citations/30883606 | http://purl.uniprot.org/core/author | "Husebye H."xsd:string |
| http://purl.uniprot.org/citations/30883606 | http://purl.uniprot.org/core/author | "Stenmark H."xsd:string |
| http://purl.uniprot.org/citations/30883606 | http://purl.uniprot.org/core/author | "Stenmark H."xsd:string |
| http://purl.uniprot.org/citations/30883606 | http://purl.uniprot.org/core/author | "Golenbock D.T."xsd:string |
| http://purl.uniprot.org/citations/30883606 | http://purl.uniprot.org/core/author | "Golenbock D.T."xsd:string |
| http://purl.uniprot.org/citations/30883606 | http://purl.uniprot.org/core/author | "Teti G."xsd:string |
| http://purl.uniprot.org/citations/30883606 | http://purl.uniprot.org/core/author | "Teti G."xsd:string |
| http://purl.uniprot.org/citations/30883606 | http://purl.uniprot.org/core/author | "Kandasamy R.K."xsd:string |
| http://purl.uniprot.org/citations/30883606 | http://purl.uniprot.org/core/author | "Kandasamy R.K."xsd:string |
| http://purl.uniprot.org/citations/30883606 | http://purl.uniprot.org/core/author | "Starheim K.K."xsd:string |
| http://purl.uniprot.org/citations/30883606 | http://purl.uniprot.org/core/author | "Starheim K.K."xsd:string |
| http://purl.uniprot.org/citations/30883606 | http://purl.uniprot.org/core/author | "Boesl K."xsd:string |
| http://purl.uniprot.org/citations/30883606 | http://purl.uniprot.org/core/author | "Boesl K."xsd:string |