| http://purl.uniprot.org/citations/31073040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31073040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31073040 | http://www.w3.org/2000/01/rdf-schema#comment | "Precise control of Wnt signaling is necessary for immune system development. In this study, we detected severely impaired development of all lymphoid lineages in mice, resulting from an N-ethyl-N-nitrosourea-induced mutation in the limb region 1-like gene (Lmbr1l), which encodes a membrane-spanning protein with no previously described function in immunity. The interaction of LMBR1L with glycoprotein 78 (GP78) and ubiquitin-associated domain-containing protein 2 (UBAC2) attenuated Wnt signaling in lymphocytes by preventing the maturation of FZD6 and LRP6 through ubiquitination within the endoplasmic reticulum and by stabilizing "destruction complex" proteins. LMBR1L-deficient T cells exhibited hallmarks of Wnt/β-catenin activation and underwent apoptotic cell death in response to proliferative stimuli. LMBR1L has an essential function during lymphopoiesis and lymphoid activation, acting as a negative regulator of the Wnt/β-catenin pathway."xsd:string |
| http://purl.uniprot.org/citations/31073040 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aau0812"xsd:string |
| http://purl.uniprot.org/citations/31073040 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aau0812"xsd:string |
| http://purl.uniprot.org/citations/31073040 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/31073040 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/31073040 | http://purl.uniprot.org/core/author | "Sun Q."xsd:string |
| http://purl.uniprot.org/citations/31073040 | http://purl.uniprot.org/core/author | "Sun Q."xsd:string |
| http://purl.uniprot.org/citations/31073040 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/31073040 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/31073040 | http://purl.uniprot.org/core/author | "Yu L."xsd:string |
| http://purl.uniprot.org/citations/31073040 | http://purl.uniprot.org/core/author | "Yu L."xsd:string |
| http://purl.uniprot.org/citations/31073040 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/31073040 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/31073040 | http://purl.uniprot.org/core/author | "Zhang D."xsd:string |
| http://purl.uniprot.org/citations/31073040 | http://purl.uniprot.org/core/author | "Zhang D."xsd:string |
| http://purl.uniprot.org/citations/31073040 | http://purl.uniprot.org/core/author | "Tang M."xsd:string |
| http://purl.uniprot.org/citations/31073040 | http://purl.uniprot.org/core/author | "Tang M."xsd:string |
| http://purl.uniprot.org/citations/31073040 | http://purl.uniprot.org/core/author | "Zhong X."xsd:string |
| http://purl.uniprot.org/citations/31073040 | http://purl.uniprot.org/core/author | "Zhong X."xsd:string |
| http://purl.uniprot.org/citations/31073040 | http://purl.uniprot.org/core/author | "Zhan X."xsd:string |
| http://purl.uniprot.org/citations/31073040 | http://purl.uniprot.org/core/author | "Zhan X."xsd:string |
| http://purl.uniprot.org/citations/31073040 | http://purl.uniprot.org/core/author | "Choi M."xsd:string |
| http://purl.uniprot.org/citations/31073040 | http://purl.uniprot.org/core/author | "Choi M."xsd:string |