| http://purl.uniprot.org/citations/3136930 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3136930 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3136930 | http://www.w3.org/2000/01/rdf-schema#comment | "The "protective protein" is a glycoprotein that associates with lysosomal beta-galactosidase and neuraminidase and is deficient in the autosomal recessive disorder galactosialidosis. We have isolated the cDNA encoding human "protective protein". The clone recognizes a 2 kb mRNA in normal cells that is not evident in fibroblasts of an early infantile galactosialidosis patient. The cDNA directs the synthesis of a 452 amino acid precursor molecule that is processed in vivo to yield mature "protective protein," a heterodimer of 32 kd and 20 kd polypeptides held together by disulfide bridges. This mature form is also biologically functional since it restores beta-galactosidase and neuraminidase activities in galactosialidosis cells. The predicted amino acid sequence of the "protective protein" bears homology to yeast carboxypeptidase Y and the KEX1 gene product. This suggests a protease activity for the "protective protein.""xsd:string |
| http://purl.uniprot.org/citations/3136930 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(88)90999-3"xsd:string |
| http://purl.uniprot.org/citations/3136930 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(88)90999-3"xsd:string |
| http://purl.uniprot.org/citations/3136930 | http://purl.uniprot.org/core/author | "Harris A."xsd:string |
| http://purl.uniprot.org/citations/3136930 | http://purl.uniprot.org/core/author | "Harris A."xsd:string |
| http://purl.uniprot.org/citations/3136930 | http://purl.uniprot.org/core/author | "Gillemans N."xsd:string |
| http://purl.uniprot.org/citations/3136930 | http://purl.uniprot.org/core/author | "Gillemans N."xsd:string |
| http://purl.uniprot.org/citations/3136930 | http://purl.uniprot.org/core/author | "Galjart N.J."xsd:string |
| http://purl.uniprot.org/citations/3136930 | http://purl.uniprot.org/core/author | "Galjart N.J."xsd:string |
| http://purl.uniprot.org/citations/3136930 | http://purl.uniprot.org/core/author | "Verheijen F.W."xsd:string |
| http://purl.uniprot.org/citations/3136930 | http://purl.uniprot.org/core/author | "Verheijen F.W."xsd:string |
| http://purl.uniprot.org/citations/3136930 | http://purl.uniprot.org/core/author | "D'Azzo A."xsd:string |
| http://purl.uniprot.org/citations/3136930 | http://purl.uniprot.org/core/author | "D'Azzo A."xsd:string |
| http://purl.uniprot.org/citations/3136930 | http://purl.uniprot.org/core/author | "Galjaard H."xsd:string |
| http://purl.uniprot.org/citations/3136930 | http://purl.uniprot.org/core/author | "Galjaard H."xsd:string |
| http://purl.uniprot.org/citations/3136930 | http://purl.uniprot.org/core/author | "van de Horst G.T.J."xsd:string |
| http://purl.uniprot.org/citations/3136930 | http://purl.uniprot.org/core/author | "van de Horst G.T.J."xsd:string |
| http://purl.uniprot.org/citations/3136930 | http://purl.uniprot.org/core/date | "1988"xsd:gYear |
| http://purl.uniprot.org/citations/3136930 | http://purl.uniprot.org/core/date | "1988"xsd:gYear |
| http://purl.uniprot.org/citations/3136930 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/3136930 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/3136930 | http://purl.uniprot.org/core/pages | "755-764"xsd:string |
| http://purl.uniprot.org/citations/3136930 | http://purl.uniprot.org/core/pages | "755-764"xsd:string |