| http://purl.uniprot.org/citations/3317417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3317417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3317417 | http://www.w3.org/2000/01/rdf-schema#comment | "Deposition of amyloid in pancreatic islets is a common feature in human type 2 diabetic subjects but because of its insolubility and low tissue concentrations, the structure of its monomer has not been determined. We describe a peptide, of calculated molecular mass 3905 Da, that was a major protein component of amyloid-rich pancreatic extracts of three type 2 diabetic patients. After collagenase treatment, an extract containing 20-50% amyloid was solubilized by sonication into 70% formic acid and the peptide was purified by gel filtration followed by reverse-phase high-performance liquid chromatography. We term this peptide diabetes-associated peptide, as it was not detected in extracts of pancreas from any of six normal subjects. Diabetes-associated peptide contains 37 amino acids and is 46% identical to the sequences of rat and human calcitonin gene-related peptide, indicating that these peptides are related in evolution. Sequence identities with conserved residues of the insulin A chain were also seen in a 16-residue segment. On extraction, the islet amyloid is particulate and insoluble like the core particles of Alzheimer disease. Their monomers have similar molecular masses, each having a hydropathic region that can probably form beta-pleated sheets. The accumulation of amyloid, including diabetes-associated peptide, in islets may impair islet function in type 2 diabetes mellitus."xsd:string |
| http://purl.uniprot.org/citations/3317417 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.84.23.8628"xsd:string |
| http://purl.uniprot.org/citations/3317417 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.84.23.8628"xsd:string |
| http://purl.uniprot.org/citations/3317417 | http://purl.uniprot.org/core/author | "Clark A."xsd:string |
| http://purl.uniprot.org/citations/3317417 | http://purl.uniprot.org/core/author | "Clark A."xsd:string |
| http://purl.uniprot.org/citations/3317417 | http://purl.uniprot.org/core/author | "Sim R.B."xsd:string |
| http://purl.uniprot.org/citations/3317417 | http://purl.uniprot.org/core/author | "Sim R.B."xsd:string |
| http://purl.uniprot.org/citations/3317417 | http://purl.uniprot.org/core/author | "Willis A.C."xsd:string |
| http://purl.uniprot.org/citations/3317417 | http://purl.uniprot.org/core/author | "Willis A.C."xsd:string |
| http://purl.uniprot.org/citations/3317417 | http://purl.uniprot.org/core/author | "Reid K.B."xsd:string |
| http://purl.uniprot.org/citations/3317417 | http://purl.uniprot.org/core/author | "Reid K.B."xsd:string |
| http://purl.uniprot.org/citations/3317417 | http://purl.uniprot.org/core/author | "Turner R.C."xsd:string |
| http://purl.uniprot.org/citations/3317417 | http://purl.uniprot.org/core/author | "Turner R.C."xsd:string |
| http://purl.uniprot.org/citations/3317417 | http://purl.uniprot.org/core/author | "Cooper G.J."xsd:string |
| http://purl.uniprot.org/citations/3317417 | http://purl.uniprot.org/core/author | "Cooper G.J."xsd:string |
| http://purl.uniprot.org/citations/3317417 | http://purl.uniprot.org/core/date | "1987"xsd:gYear |
| http://purl.uniprot.org/citations/3317417 | http://purl.uniprot.org/core/date | "1987"xsd:gYear |
| http://purl.uniprot.org/citations/3317417 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/3317417 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/3317417 | http://purl.uniprot.org/core/pages | "8628-8632"xsd:string |
| http://purl.uniprot.org/citations/3317417 | http://purl.uniprot.org/core/pages | "8628-8632"xsd:string |
| http://purl.uniprot.org/citations/3317417 | http://purl.uniprot.org/core/title | "Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients."xsd:string |
| http://purl.uniprot.org/citations/3317417 | http://purl.uniprot.org/core/title | "Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients."xsd:string |