| http://purl.uniprot.org/citations/3756141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3756141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3756141 | http://www.w3.org/2000/01/rdf-schema#comment | "The primary structure of human C1 inhibitor was determined by peptide and DNA sequencing. The single-chain polypeptide moiety of the intact inhibitor is 478 residues (52,869 Da), accounting for only 51% of the apparent molecular mass of the circulating protein (104,000 Da). The positions of six glucosamine-based and five galactosamine-based oligosaccharides were determined. Another nine threonine residues are probably also glycosylated. Most of the carbohydrate prosthetic groups (probably 17) are located at the amino-terminal end (residues 1-120) of the protein and are particularly concentrated in a region where the tetrapeptide sequence Glx-Pro-Thr-Thr, and variants thereof, is repeated 7 times. No phosphate was detected in C1 inhibitor. Two disulfide bridges connect cysteine-101 to cysteine-406 and cysteine-108 to cysteine-183. Comparison of the amino acid and cDNA sequences indicates that secretion is mediated by a 22-residue signal peptide and that further proteolytic processing does not occur. C1 inhibitor is a member of the large serine protease inhibitor (serpin) gene family. The homology concerns residues 120 through the C-terminus. The sequence was compared with those of nine other serpins, and conserved and nonconserved regions correlated with elements in the tertiary structure of alpha 1-antitrypsin. The C1 inhibitor gene maps to chromosome 11, p11.2-q13. C1 inhibitor genes of patients from four hereditary angioneurotic edema kindreds do not have obvious deletions or rearrangements in the C1 inhibitor locus. A HgiAI DNA polymorphism, identified following the observation of sequence variants, will be useful as a linkage marker in studies of mutant C1 inhibitor genes."xsd:string |
| http://purl.uniprot.org/citations/3756141 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi00363a018"xsd:string |
| http://purl.uniprot.org/citations/3756141 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi00363a018"xsd:string |
| http://purl.uniprot.org/citations/3756141 | http://purl.uniprot.org/core/author | "Huber R."xsd:string |
| http://purl.uniprot.org/citations/3756141 | http://purl.uniprot.org/core/author | "Huber R."xsd:string |
| http://purl.uniprot.org/citations/3756141 | http://purl.uniprot.org/core/author | "Eddy R.L."xsd:string |
| http://purl.uniprot.org/citations/3756141 | http://purl.uniprot.org/core/author | "Eddy R.L."xsd:string |
| http://purl.uniprot.org/citations/3756141 | http://purl.uniprot.org/core/author | "Magnusson S."xsd:string |
| http://purl.uniprot.org/citations/3756141 | http://purl.uniprot.org/core/author | "Magnusson S."xsd:string |
| http://purl.uniprot.org/citations/3756141 | http://purl.uniprot.org/core/author | "Shows T.B."xsd:string |
| http://purl.uniprot.org/citations/3756141 | http://purl.uniprot.org/core/author | "Shows T.B."xsd:string |
| http://purl.uniprot.org/citations/3756141 | http://purl.uniprot.org/core/author | "Wiman B."xsd:string |
| http://purl.uniprot.org/citations/3756141 | http://purl.uniprot.org/core/author | "Wiman B."xsd:string |
| http://purl.uniprot.org/citations/3756141 | http://purl.uniprot.org/core/author | "Nielsen E."xsd:string |
| http://purl.uniprot.org/citations/3756141 | http://purl.uniprot.org/core/author | "Nielsen E."xsd:string |
| http://purl.uniprot.org/citations/3756141 | http://purl.uniprot.org/core/author | "Skriver K."xsd:string |
| http://purl.uniprot.org/citations/3756141 | http://purl.uniprot.org/core/author | "Skriver K."xsd:string |
| http://purl.uniprot.org/citations/3756141 | http://purl.uniprot.org/core/author | "Bock S.C."xsd:string |
| http://purl.uniprot.org/citations/3756141 | http://purl.uniprot.org/core/author | "Bock S.C."xsd:string |
| http://purl.uniprot.org/citations/3756141 | http://purl.uniprot.org/core/author | "Radziejewska E."xsd:string |
| http://purl.uniprot.org/citations/3756141 | http://purl.uniprot.org/core/author | "Radziejewska E."xsd:string |
| http://purl.uniprot.org/citations/3756141 | http://purl.uniprot.org/core/author | "Donaldson V.H."xsd:string |
| http://purl.uniprot.org/citations/3756141 | http://purl.uniprot.org/core/author | "Donaldson V.H."xsd:string |